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首页> 美国卫生研究院文献>Jornal Vascular Brasileiro >Hiperplasia angiolinfoide com eosinofilia: um caso raro em cavidade oral
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Hiperplasia angiolinfoide com eosinofilia: um caso raro em cavidade oral

机译：血管性信息素增生伴嗜酸性粒细胞增多：口腔内罕见病例

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摘要

Angiolymphoid Hyperplasia with eosinophilia (ALHE) is considered a rare, benign vascular lesion that mainly affects the skin and subcutaneous tissues of the head and neck, but is uncommon in the oral cavity. Its etiology remains unclear and it has been described as a reactive vascular proliferation, vascular malformation or neoplasm. Kimura's disease is the primary entity to consider in differential diagnosis. Here we report on a rare case of ALHE involving the upper lip of a 50-year-old male patient that had a nodular swelling with approximately 3 cm, 7 years after initial onset. An excisional biopsy was performed and histopathologic examination revealed a well-encapsulated, multi-lobed lesion with proliferation of blood capillaries, displaying endothelial cells of epithelioid appearance, diffuse inflammatory infiltrate with lymphocytes, plasma cells, numerous eosinophils, and presence of lymphoid follicles. Immunohistochemical tests were positive for the markers CD34 and Ki-67 that, in combination with the results of morphological examination, were suggestive of a diagnosis of ALHE.
机译：<！-front-stub->具有嗜酸性粒细胞增多症（ALHE）的淋巴管增生被认为是一种罕见的良性血管病变，主要累及头颈部的皮肤和皮下组织，但在口腔中并不常见。其病因尚不清楚，已被描述为反应性血管增生，血管畸形或肿瘤。木村病是鉴别诊断中要考虑的主要因素。在这里，我们报道了一个罕见的ALHE病例，该病例涉及一名50岁男性患者的上唇，该患者在初次发病后7年出现了约3 cm的结节性肿胀。进行了切除活检，并进行了组织病理学检查，发现一个包封的多叶病变，毛细血管增生，显示上皮样细胞的内皮细胞出现，淋巴细胞，浆细胞，大量嗜酸性粒细胞弥漫性炎症浸润，以及淋巴滤泡的存在。标记CD34和Ki-67的免疫组织化学检测呈阳性，结合形态学检查结果，提示诊断为ALHE。

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