首页> 美国卫生研究院文献>Journal of Thoracic Disease >Tissue requirements in lung cancer diagnosis for tumor heterogeneity mutational analysis and targeted therapies: initial experience with intra-operative Frozen Section Evaluation (FROSE) in bronchoscopic biopsies
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Tissue requirements in lung cancer diagnosis for tumor heterogeneity mutational analysis and targeted therapies: initial experience with intra-operative Frozen Section Evaluation (FROSE) in bronchoscopic biopsies

机译:肺癌诊断中的组织要求用于肿瘤异质性突变分析和靶向治疗:支气管镜活检术中术中冰冻切片评估(FROSE)的初步经验

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摘要

BackgroundRecent advances in lung cancer treatment have changed the requirement for the amount and quality of biopsy specimens needed to characterize the tumor and select the best treatment. One adjunct to guide the bronchoscopist on the quality and quantity of specimens during bronchoscopic biopsies for the diagnosis of lung cancer is rapid on-site evaluation (ROSE) of cytological specimens. This technique has been shown to add to the diagnostic yield of bronchoscopy when obtaining adequate specimens for molecular profiling in lung cancer. ROSE is not available at all medical centers. We describe our initial experience using intra-procedural Frozen Section Evaluation (FROSE) of bronchoscopic biopsy specimens as an alternative to ROSE.
机译:背景技术肺癌治疗的最新进展已改变了对表征肿瘤和选择最佳治疗方法所需的活检标本的数量和质量的要求。在支气管镜活检过程中指导支气管镜医师检查标本质量和数量的一种辅助手段是对细胞标本进行快速现场评估(ROSE)。当获得足够的肺癌分子谱分析标本时,该技术已被证明可增加支气管镜的诊断率。不是所有医疗中心都提供ROSE。我们描述了使用支气管镜活检标本的过程内冷冻切片评估(FROSE)替代ROSE的初步经验。

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