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Hormone receptor–positive HER2-negative metastatic breast cancer: redrawing the lines

机译:激素受体阳性HER2阴性转移性乳腺癌:重划思路

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摘要

Estrogen receptor modulators and estrogen deprivation have become standards of care for hormone receptor–positive metastatic breast cancer. However, after traditional first-line endocrine monotherapy treatment, the disease typically progresses despite the initial high rate of clinical benefit. Multiple studies have aimed at optimizing treatment strategies to improve upon clinical benefit beyond the traditional single-agent endocrine treatment. With the availability of new data and novel therapies, the clinical practice challenge becomes how best to define the optimal treatment sequence to maximize clinical benefit. In this review, we present treatment options clinically relevant to the management of hormone-positive, her2-negative metastatic breast cancer, and we propose a treatment algorithm based on the current literature.
机译:雌激素受体调节剂和雌激素剥夺已成为激素受体阳性转移性乳腺癌的治疗标准。但是,在传统的一线内分泌单药治疗之后,尽管最初的临床获益率很高,但疾病通常会进展。多项研究旨在优化治疗策略,以改善传统单药内分泌治疗的临床疗效。随着新数据和新疗法的获得,临床实践面临的挑战成为如何最好地定义最佳治疗顺序以最大程度地提高临床收益。在这篇综述中,我们介绍了临床上与激素阳性,her2阴性转移性乳腺癌的治疗相关的治疗方案,并根据当前文献提出了一种治疗算法。

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