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Bench-to-bedside review: Toll-like receptors and their role in septic shock

机译:从床到床的回顾:Toll样受体及其在败血性休克中的作用

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摘要

The Toll-like receptors (TLRs) are essential transmembrane signaling receptors of the innate immune system that alert the host to the presence of a microbial invader. The recent discovery of the TLRs has rapidly expanded our knowledge of molecular events that initiate host–pathogen interactions. These functional attributes of the cellular receptors provide insights into the nature of pattern recognition receptors that activate the human antimicrobial defense systems. The fundamental significance of the TLRs in the generation of systemic inflammation and the pathogenesis of septic shock is reviewed. The potential clinical implications of therapeutic modulation of these recently characterized receptors of innate immunity are also discussed.
机译:Toll样受体(TLR)是先天性免疫系统必不可少的跨膜信号转导受体,可提醒宿主微生物入侵者的存在。 TLR的最新发现迅速扩展了我们对引发宿主与病原体相互作用的分子事件的了解。细胞受体的这些功能属性为激活人类抗菌防御系统的模式识别受体的性质提供了见识。综述了TLR在系统性炎症的发生和败血性休克的发病机理中的基本意义。还讨论了治疗性调节这些最近表征的先天免疫受体的潜在临床意义。

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