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Expert opinion on therapeutic targets

Expert opinion on therapeutic targets

SCIMEDLINE

中文名称：专家意见的治疗目标

ISSN：1472-8222
出版周期：Bimonthly

发文量：1473

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1.Extracellular HMGB1 as a therapeutic target in inflammatory diseases?

机译：细胞外HMGB1作为炎性疾病的治疗靶标吗？
- 作者：Ulf Andersson;Huan Yang;Helena Harris
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第6期
2.Emerging therapeutic targets currently under investigation for the treatment of systemic amyloidosis

机译：目前正在调查的新兴治疗目标用于治疗全身淀粉样蛋白病
- 作者：Nuvolone Mario;Merlini Giampaolo
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第12期
3.Targeting fusion proteins: a double edge sword?

机译：靶向融合蛋白：双刃剑？
- 作者：Oscar M. Tirado
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第12期
- Translocation-associated sarcomas;
- fusion proteins;
- metastasis;
- targeted therapy;
4.Targeting endothelin-1 receptor/beta-arrestin1 network for the treatment of ovarian cancer

机译：靶向内皮素-1受体/β-ARRESTIN1网络治疗卵巢癌
- 作者：Rosano Laura;Cianfrocca Roberta;Sestito Rosanna;Tocci Piera;Di Castro Valeriana;Bagnato Anna
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第12期
- Endothelin-1;
- beta-arrestin-1;
- ovarian cancer;
- ET-1 receptors;
- therapeutic target;
- ET-1 receptor antagonist;
5.Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport

机译：椎骨上皮运输障碍症中Phak激酶的药理靶向
- 作者：Zhang Jinwei;Karimy Jason K.;Delpire Eric;Kahle Kristopher T.
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第12期
6.The importance of targeting HIV reservoirs: preclinical insights on current and potential therapeutic opportunities

机译：针对艾滋病毒储层的重要性：对当前和潜在治疗机会的临床前见解
- 作者：Theodore J Cory
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第12期
- HIV-1;
- viral reservoir;
- shock and kill;
- block and lock;
- tissue reservoir;
7.The potential utility of PFKFB3 as a therapeutic target

机译：PFKFB3作为治疗目标的潜在效用
- 作者：Ramon Bartrons;Ana Rodrfguez-Garcfa;Helga Simon-Molas;Esther Castano;Anna Manzano;Aurea Navarro-Sabate
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第12期
- Cancer;
- glycolysis;
- metabolism;
- PFKFB3;
- PFKFB3 inhibitors;
8.Notch signaling as a therapeutic target for acute lymphoblastic leukemia?

机译：Notch信号传导作为急性淋巴细胞白血病的治疗靶标？
- 作者：Diana Bellavia;Rocco Palermo;Maria Pia Felli
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第6期
9.Neuronal and behavioral plasticity: the role of serotonin and BDNF systems tandem

机译：神经元和行为可塑性：血清素和BDNF系统的作用串联
- 作者：Popova Nina K.;Naumenko Vladimir S.
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第6期
- Brain;
- brain-derived neurotrophic factor (BDNF);
- serotonin;
- 5-HT;
- behavior;
- BDNF-5-HT interaction;
- aggression;
- depression;
- stress;
10.The macrophage as a Trojan horse for antisense oligonucleotide delivery

机译：巨噬细胞作为脱义寡核苷酸递送的特洛伊木马
- 作者：Novak James S.;Jaiswal Jyoti K.;Partridge Terence A.
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第6期
- Duchenne muscular dystrophy;
- antisense oligonucleotides;
- exon skipping;
- satellite cells;
- macrophages;
- drug delivery;
11.Targeting the cell signaling pathway Keap1-Nrf2 as a therapeutic strategy for adenocarcinomas of the lung

机译：靶向细胞信号传导途径Keap1-NRF2作为肺癌腺癌的治疗策略
- 作者：Zhang Bo;Ma Zhiyuan;Tan Biqin;Lin Nengming
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第6期
- Keap1;
- Nrf2;
- lung;
- adenocarcinoma;
- targets;
12.Therapeutical potential of deregulated lysine methyltransferase SMYD3 as a safe target for novel anticancer agents

机译：解毒赖氨酸甲基转移酶Smyd3作为新型抗癌剂的安全靶点
- 作者：Rajajeyabalachandran Gurukumari;Kumar Swetha;Murugesan Thanabal;Ekambaram Shanthi;Padmavathy Ramya;Jegatheesan Sooriya Kumar;Mullangi Ramesh;Rajagopal Sriram
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第6期
- Anticancer;
- cancer;
- EPZ031686;
- GSK2807;
- histone;
- LOXL2;
- lysine methyltransferase;
- MAP3K2;
- RB1;
- RIZ1;
- SMYD3;
13.Preclinical insights into cholangiopathies: disease modeling and emerging therapeutic targets

机译：胆管素病的临床前见解：疾病建模和新兴治疗目标
- 作者：Sato Keisaku;Glaser Shannon;Kennedy Lindsey;Liangpunsakul Suthat;Meng Fanyin;Francis Heather;Alpini Gianfranco
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第6期
- Cholangiopathy;
- bile duct;
- cholangiocyte;
- inflammation;
- liver fibrosis;
14.Inflammation resolution and specialized pro-resolving lipid mediators in CNS diseases

机译：CNS疾病中的炎症分辨率和专业的Pro-solating脂质介质
- 作者：Pei Shang;Ying Zhang;Di Ma;Yulei Hao;Xinyu Wang;Meiying Xin;Yunhai Zhang;Mingqin Zhu;Jiachun Feng
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第12期
15.Immunological mutational signature in adenosquamous cancer of pancreas: an exploratory study of potentially therapeutic targets?

机译：胰腺癌腺癌中的免疫突变签名：潜在治疗靶标的探索性研究？
- 作者：Nicola Silvestris;Oronzo Brunetti;Rosamaria Pinto;Daniela Petriella
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第6期
16.Exploiting the pro-apoptotic function of NOXA as a therapeutic modality in cancer

机译：利用NOXA作为癌症治疗方式的亲凋亡函数
- 作者：Guikema Jeroen E.;Amiot Martine;Eldering Eric
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第12期
- Apoptosis;
- Bcl-2 family;
- Noxa;
- Mcl-1;
17.Galectin-3: is this member of a large family of multifunctional lectins (already) a therapeutic target?

机译：Galectin-3：这是一家大型多功能凝集素（已经）治疗目标的成员吗？
- 作者：Antonio Romero;Hans-Joachim Gabius
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第12期
- Adhesion;
- apoptosis;
- galectin-3 (Gal-3);
- glycans;
- glycoproteins;
- polysaccharides;
18.Epigenomic therapies: the potential of targeting SIRT6 for the treatment of pancreatic cancer

机译：表观胸肉疗法：靶向SIRT6用于治疗胰腺癌的潜力
- 作者：Demir Ihsan Ekin;Ceyhan Guralp O.;Friess Helmut
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第6期
- Pancreatic cancer;
- SIRT6;
- histone deacetylase;
- methylation;
- Lin28b;
- let-7;
- epigenetics;
19.Role of osteopontin as a predictive biomarker for anti-EGFR therapy in triple-negative breast cancer

机译：骨桥蛋白作为三重阴性乳腺癌抗EGFR治疗的预测生物标志物的作用
- 作者：Pieter H. Anborgh;Danny J. Lee;Pieter F. Stam;Alan B. Tuck;Ann F. Chambers
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第12期
- Osteopontin;
- anti-EGFR therapy;
- breast cancer;
- erlotinib;
- predictive;
- biomarker;
20.Nutrient sensing pathways as therapeutic targets for healthy ageing

机译：营养传感途径作为健康老化的治疗目标
- 作者：Aiello Anna;Accardi Giulia;Candore Giuseppina;Gambino Caterina Maria;Mirisola Mario;Taormina Giusi;Virruso Claudia;Caruso Calogero
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第6期
- Aging;
- anti-aging approaches;
- dietary patterns;
- nutraceuticals;
- nutrient sensing pathways;
21.Targeting fundamental aging mechanisms to treat osteoporosis

机译：针对基本老化机制来治疗骨质疏松症
- 作者：Jack Feehan;Ahmed Al Saedi;Gustavo Duque
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第12期
- Osteoporosis;
- Anabolics;
- aging;
- kynurenines;
- Wnts;
- RANKL;
- Sclerostin;
- Osteosarcopenia;
- Antiresorptives;
22.Sequestosome 1/p62-related pathways as therapeutic targets in hepatocellular carcinoma

机译：与肝细胞癌的治疗靶标有关的杀囊肿1 / p62相关途径
- 作者：Denk Helmut;Stumptner Conny;Abuja Peter M.;Zatloukal Kurt
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第6期
- Sequestosome1;
- p62;
- hepatocellular carcinoma (HCC);
- signaling pathways;
- autophagy;
- apoptosis;
- oxidative stress;
- inclusion bodies;
- Mallory-Denk bodies;
- intracellular hyaline bodies;
23.The apelin/APJ system as a therapeutic target in metabolic diseases

机译：Apelin / APJ系统作为代谢疾病的治疗靶标
- 作者：Castan-Laurell Isabelle;Masri Bernard;Valet Philippe
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第6期
- Apelin;
- obesity;
- type 2 diabetes;
- energy metabolism;
- apelin/APJ system;
24.Therapeutic targets for the treatment of microsporidiosis in humans

机译：治疗人体孢子虫治疗的治疗靶
- 作者：Bing Han;Louis M. Weiss
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第12期
- Microsporidia;
- microsporidiosis;
- therapeutic targets;
- diagnosis;
- triosephosphate isomerase;
- tubulin;
- methionine aminopeptidase 2;
- Chitin synthases;
- polyamines;
25.Cystic Fibrosis: Proteostatic correctors of CFTR trafficking and alternative therapeutic targets.

机译：囊性纤维化：CFTR贩运和替代治疗目标的蛋白质矫形校正器。
- 作者：John W. Hanrahan;Yukiko Sato;Graeme W. Carlile;Gregor Jansen;Jason C. Young;David Y. Thomas
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第12期
- Proteostasis modulators;
- cystic fibrosis;
- protein trafficking;
- quality control;
26.Signaling pathways as therapeutic targets in biliary tract cancer

机译：作为胆道癌症的治疗靶标的信号传导途径
- 作者：Yang Jennifer;Farren Matthew R.;Ahn Daniel;Bekaii-Saab Tanios;Lesinski Gregory B.
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第6期
- Biliary tract cancer;
- cholangiocarcinoma;
- targeted therapy;
- STAT3;
- PI3K;
- MEK;
27.Garp as a therapeutic target for modulation of T regulatory cell function

机译：Garp作为调制T调节细胞功能的治疗靶标
- 作者：Shevach Ethan M.
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第6期
- GARP;
- latent TGF-beta;
- T regulatory cells;
- foxp3;
- suppression;
- integrins;
28.Potential mechanisms underlying CDK5 related Osteosarcoma progression

机译：CDK5相关骨肉瘤进展的潜在机制
- 作者：Bao Hang-xing;Bi Qing;Han Yong;Zhao Chen;Zou Hai
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第6期
- Osteosarcoma;
- cyclin-dependent kinase 5;
- tumor immune escape;
- therapeutic targets;
29.Hereditary angioedema: examining the landscape of therapies and preclinical therapeutic targets

机译：遗传性血统模型：检查疗法和临床前治疗目标的景观
- 作者：Farkas Henriette
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第6期
- Hereditary angioedema;
- kallikrein;
- bradykinin;
- recombinant;
- monoclonal antibody;
- Factor XII;
- gene therapy;
- C1-inhibitor;
- prekallikrein;
30.Targeting toll-like receptor 4 to modulate neuroinflammation in central nervous system disorders

机译：靶向Toll样受体4以调节中枢神经系统疾病中的神经炎症
- 作者：Gunnar R. Leitner;Tyler J. Wenzel;Nick Marshall;Ellen J. Gates;Andis Klegeris
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第12期
- Alzheimer's disease;
- astrocytes;
- cytokines;
- microglia;
- neurodegeneration;
- neuroinflammation;
- Parkinson's disease;
- MyD88;
- toll-like receptors;
31.Targeting CPS1 in the treatment of Carbamoyl phosphate synthetase 1 (CPS1) deficiency, a urea cycle disorder

机译：靶向CPS1在治疗氨基甲酰磷酸合成酶1（CPS1）缺乏，尿素循环障碍
- 作者：Diez-Fernandez Carmen;Haeberle Johannes
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第6期
- Urea cycle disorders;
- carbamoyl phosphate synthetase 1;
- N-carbamoyl-L-glutamate;
- pharmacological chaperones;
- gene therapy;
- flavonoids;
32.The potential of aldehyde dehydrogenase 2 as a therapeutic target in cardiovascular disease?

机译：醛脱氢酶2作为心血管疾病治疗靶标的潜力？
- 作者：Thomas Münzel;Andreas Daiber
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第6期
33.The potential of AR-V7 as a therapeutic target?

机译：Ar-V7作为治疗目标的潜力？
- 作者：Takuma Uo;Stephen R. Plymate;Cynthia C. Sprenger
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第6期
34.GRK2 as a therapeutic target for heart failure?

机译：GRK2作为心力衰竭的治疗目标？
- 作者：Alessro Cannavo;Klara Komici;Leonardo Bencivenga
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第6期
35.The potential of FimH as a novel therapeutic target for the treatment of Crohn's disease

机译：FIMH作为治疗克罗恩病的新疗效目标
- 作者：Sivignon Adeline;Bouckaert Julie;Bernard Julien;Gouin Sebastien G.;Barnich Nicolas
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第12期
- FimH antagonists;
- personalized therapy;
- microbiota-targeting therapy;
- mannosides;
- Escherichia coli;
36.Alopecia areata and the gut-the link opens up for novel therapeutic interventions

机译：Alopecia Areata和肠道 - 该联系开辟了新的治疗干预措施
- 作者：Borde Annika;Astrand Annika
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第6期
- Alopecia areata;
- intestinal permeability;
- chronic inflammation;
- autoimmunity;
37.The emergence of Ephexin5 as a therapeutic target in Alzheimer's disease

机译：Ephexin5作为阿尔茨海默病的治疗靶标的出现
- 作者：Cook Emily K.;Sell Gabrielle L.;Schaffer Thomas B.;Margolis Seth S.
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第6期
38.DEPDC5 as a potential therapeutic target for epilepsy

机译：DEPDC5作为癫痫的潜在治疗靶标
- 作者：Myers Kenneth A.;Scheffer Ingrid E.
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第6期
- DEPDC5;
- focal epilepsy;
- NPRL2;
- NPRL3;
- GATOR1;
- mechanistic target of rapamycin;
- tuberous sclerosis;
- cortical dysplasia;
- rapamycin;
39.Pro-resolving lipid mediators as therapeutic leads for cardiovascular diseases

机译：作为心血管疾病的治疗引线进行脂质介质
- 作者：Cheng Yuanyuan;Rong Jianhui
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第6期
- Cardiovascular diseases;
- lipid mediators;
- bioinformatics analysis;
- pre-resolution;
- network pharmacology analysis;
40.KSR as a therapeutic target for Ras-dependent cancers

机译：KSR作为RAS依赖性癌症的治疗靶标
- 作者：Neilsen Beth K.;Frodyma Danielle E.;Lewis Robert E.;Fisher Kurt W.
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第6期
- APS-2-79;
- cancer therapeutics;
- ERK;
- Kinase Suppressor of Ras;
- KSR1;
- KSR2;
- MEK;
- Raf;
- Ras-dependent cancers;
- Ras signaling;
41.Chaperone-mediated autophagy as a therapeutic target for Parkinson disease

机译：伴侣介导的自噬作为帕金森病的治疗靶标
- 作者：Philip Campbell;Huw Morris;Anthony Schapira
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第12期
- Chaperone-mediated autophagy;
- Parkinson disease;
- therapeutics;
- lysosome;
- mitochondrial function;
- proteostasis;
- a-synuclein;
42.Interstitial fluid flow under the microscope: is it a future drug target for high grade brain tumours such as glioblastoma?

机译：显微镜下的间质液体流动：是对胶质母细胞瘤等高级脑肿瘤的未来药物目标吗？
- 作者：Jennifer M. Munson
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第12期
43.Molecular links between COPD and lung cancer: new targets for drug discovery?

机译：COPD和肺癌之间的分子环节：药物发现的新目标？
- 作者：Caramori Gaetano;Ruggeri Paolo;Mumby Sharon;Ieni Antonio;Lo Bello Federica;Chaminka Vrushali;Donovan Chantal;Ando Filippo;Nucera Francesco;Coppolino Irene;Tuccari Giovanni;Hansbro Philip M.;Adcock Ian M.
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第6期
- COPD;
- lung cancer;
- smoking;
- squamous cell carcinoma;
44.Targeting protein kinase-b3 (akt3) signaling in melanoma

机译：在黑色素瘤中靶向蛋白激酶-B3（AKT3）信号传导
- 作者：Madhunapantula SubbaRao V.;Robertson Gavin P.
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第6期
- AKT3;
- Akt inhibitors;
- drug resistance;
- melanoma;
- PI3K;
- PRAS40;
- PTEN;
45.Role of 'shared epitope' and other citrullination-sites in rheumatoid arthritis and in melanoma

机译：“共用表位”和其他瓜氨酸关节炎和黑色素瘤的作用的作用
- 作者：DArcangelo Daniela;Facchiano Antonio;Facchiano Angelo M.
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第12期
46.Targeting SOX2 in anticancer therapy

机译：靶向SOX2在抗癌治疗中
- 作者：Hueser Laura;Novak Daniel;Umansky Viktor;Altevogt Peter;Utikal Jochen
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第12期
- Cancer;
- SOX2;
- therapeutic targets;
- therapy resistance;
- resistance;
- tumor;
47.Does HERV-K represent a potential therapeutic target for prostate cancer?

机译：Herv-k是否代表了前列腺癌的潜在治疗靶标？
- 作者：Schulz Wolfgang A.
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第12期
- Prostate cancer;
- endogenous retrovirus;
- HERV-K;
- Gag protein;
- anti-androgenic therapy;
- autoantibodies;
- vaccine;
- active surveillance;
48.Trabecular meshwork ECM remodeling in glaucoma: could RAS be a target?

机译：在青光眼中的小梁网状ECM重塑：ras是一个目标吗？
- 作者：Puneet Agarwal;Renu Agarwal
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第12期
- Extracellular matrix;
- trabecular meshwork;
- renin-angiotensin system;
- intraocular pressure;
- transforming growth factor;
49.The eIF2-alpha kinase HRI: a potential target beyond the red blood cell

机译：EIF2-α激酶HRI：超出红细胞的潜在目标
- 作者：Burwick Nicholas;Aktas Bertal H.
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第12期
- Cancer;
- eIF2;
- HRI;
- translation;
- ER stress;
50.Competitive endogenous RNA network: potential implication for systemic lupus erythematosus

机译：竞争内源性RNA网络：系统性狼疮红斑狼疮的潜在含义
- 作者：Li Lian-Ju;Zhao Wei;Tao Sha-Sha;Leng Rui-Xue;Fan Yin-Guang;Pan Hai-Feng;Ye Dong-Qing
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第6期
- ceRNA;
- SLE;
- miRNA;
- lncRNA;
- circRNA;
- pseudogene;
51.GPER-1/GPR30 a novel estrogen receptor sited in the cell membrane: therapeutic coupling to breast cancer

机译：GPER-1 / GPR30在细胞膜中具有新的雌激素受体：治疗偶联与乳腺癌
- 作者：Molina Luis;Figueroa Carlos D.;Bhoola Kanti D.;Ehrenfeld Pamela
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第12期
- Estrogen receptors;
- GPER-1;
- GPR30;
- breast cancer;
- tamoxifen;
- endocrine therapy;
- signaling pathways;
52.The accessory gene regulator-1 as a therapeutic target for C-difficile infections

机译：辅助基因调节剂-1作为C-艰难梭菌感染的治疗靶标
- 作者：Darkoh Charles;DuPont Herbert L.
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第6期
53.The potential of dopamine receptor D2 (DRD2) as a therapeutic target for tackling pancreatic cancer

机译：多巴胺受体D2（DRD2）作为治疗胰腺癌的治疗靶标的潜力
- 作者：Bakadlag Rowa;Jandaghi Pouria;Hoheisel Joerg D.;Riazalhosseini Yasser
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第6期
- Cancer;
- chemotherapy;
- DRD2;
- drug-repositioning;
- haloperidol;
- pimozide;
- pancreatic ductal adenocarcinoma;
54.How to say NO to vascular disruption and stem cell mobilization

机译：如何对血管破坏和干细胞动员说不
- 作者：Diana Passaro;Dominique Bonnet
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第12期
- Nitric oxide;
- vascular niche;
- acute myeloid leukemia;
- bone marrow;
- hematopoietic stem cells;
55.The potential of PTPN22 as a therapeutic target for rheumatoid arthritis

机译：PTPN22的潜力作为类风湿性关节炎的治疗靶标
- 作者：F. David Carmona;Javier Martfn
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第12期
- Rheumatoid arthritis;
- PTPN22;
- LYP inhibitors;
- T cells;
- TCR;
56.Endoglin and alk1 as therapeutic targets for hereditary hemorrhagic telangiectasia

机译：endoglan和Alk1作为遗传性出血性毛细管扩张的治疗目标
- 作者：Ruiz-Llorente Lidia;Gallardo-Vara Eunate;Rossi Elisa;Smadja David M.;Botella Luisa M.;Bernabeu Carmelo
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第12期
- HHT;
- endoglin;
- ALK1;
- haploinsufficiency;
- bleeding;
- angiogenesis;
- AVM;
- bevacizumab;
- thalidomide;
57.Potential targets of gene therapy in the treatment of heart failure

机译：基因治疗治疗心力衰竭的潜在目标
- 作者：Jakub Rosik;Bartosz Szostak;Filip Machaj;Andrzej Pawlik
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第12期
- SERCA2a;
- S100A1;
- IPP-1;
- gene therapy;
- heart failure;
- SUM01;
58.Emerging molecular therapeutic targets for spinal cord injury

机译：脊髓损伤的新兴分子治疗靶标
- 作者：Shuo Wang;George M Smith;Michael E. Selzer;Shuxin Li
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第12期
- Spinal cord injury;
- neuroprotection;
- axon regeneration;
- epigenetic;
- remyelination;
- inflammation;
- astrogliosis;
- axon growth inhibitor;
- molecular therapy;
- functional recovery;
59.Therapeutic approaches for targeting receptor tyrosine kinase like orphan receptor-1 in cancer cells

机译：用于靶向酪氨酸激酶的治疗方法，如癌细胞中的孤儿受体-1
- 作者：Kamrani Amin;Mehdizadeh Amir;Ahmadi Majid;Aghebati-Maleki Leili;Yousefi Mehdi
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第6期
- Receptor tyrosine kinas like orphan;
- ROR-1;
- targeted therapy;
- immunotherapy;
- cancer;
60.Current and emerging paradigms in the therapeutic management of atherosclerosis.

机译：动脉粥样硬化治疗管理中的当前和新兴范式。
- 作者：Tiwari A
- 期刊名称：《Expert opinion on therapeutic targets》 | 2008年第12期
- Atherosclerosis;
- drug discovery;
- paradigm;
- Current;
- 动脉粥样硬化;
61.MUC16 as a novel target for cancer therapy

机译：Muc16作为癌症治疗的新靶点
- 作者：Abhijit Aithal;Sanchita Rauth;Prakash Kshirsagar;Ashu Shah;Imayavaramban Lakshmanan;Wade M. Junker;Maneesh Jain;Moorthy P. Ponnusamy;Surinder K. Batra
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第12期
- MUC16;
- cancer therapy;
- mucins;
- immunotherapy;
- targeted therapy;
62.Targeting pancreatic expressed PAX genes for the treatment of diabetes mellitus and pancreatic neuroendocrine tumors

机译：针对胰腺表达的PAX基因用于治疗糖尿病和胰腺神经内分泌肿瘤
- 作者：Martin-Montalvo Alejandro;Lorenzo Petra I.;Lopez-Noriega Livia;Gauthier Benoit R.
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第6期
- Diabetes mellitus;
- pancreatic neuroendocrine tumors;
- PAX genes;
- PAX2;
- PAX4;
- PAX6;
- PAX8;
63.Epigenetic modifications in multiple myeloma: recent advances on the role of DNA and histone methylation

机译：多发性骨髓瘤中的表观遗传修饰：最近对DNA和组蛋白甲基化作用的进展
- 作者：Amodio Nicola;DAquila Patrizia;Passarino Giuseppe;Tassone Pierfrancesco;Bellizzi Dina
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第6期
- DNA methylation;
- epigenetic therapies;
- histone methylation;
- microRNA;
- miRNA;
- multiple myeloma;
- multiple myeloma epigenetics;
- non-coding RNAs;
64.HIF-a factors as potential therapeutic targets in leukemia

机译：HIF-白血病潜在治疗靶标的因素
- 作者：Daniela Magliulo;Rosa Bernards
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第12期
- HIF;
- HIF inhibitors;
- hematopoiesis;
- hematopoietic stem cells (HSCs);
- hypoxia;
- leukemia;
- leukemia stem cells (LSCs);
65.Hypoxia-inducible factor-1: a promising therapeutic target for autoimmune diseases

机译：缺氧诱导因子-1：自身免疫疾病的有希望的治疗靶标
- 作者：Guan Shi-Yang;Leng Rui-Xue;Tao Jin-Hui;Li Xiang-Pei;Ye Dong-Qing;Olsen Nancy;Zheng Song Guo;Pan Hai-Feng
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第12期
- Autoimmune diseases;
- hypoxia-inducible factor-1;
- inflammation;
- therapeutic target;
66.TDP-43 post-translational modifications in health and disease

机译：TDP-43健康和疾病的翻译后修饰
- 作者：Emanuele Buratti
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第6期
67.Endoglin and alk1 as therapeutic targets for hereditary hemorrhagic telangiectasia (vol 20, pg 1, 2017)

机译：endoglin和Alk1作为遗传性出血性胞菌疾病的治疗目标（Vol 20，PG 1，2017）
- 作者：Ruiz-Llorente L.;Gallardo-Vara E.;Rossi E.
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第12期
68.Recent advances in targeting protein arginine methyltransferase enzymes in cancer therapy

机译：靶向蛋白质精氨酸甲基转移酶在癌症治疗中的最新进展
- 作者：Smith Emily;Zhou Wei;Shindiapina Polina;Sif Said;Li Chenglong;Baiocchi Robert A.
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第6期
- Cancer;
- arginine-methylation;
- epigenetics;
- therapeutic target;
69.Functional genetic evaluation of DNA house-cleaning enzymes in the malaria parasite: dUTPase and Ap4AH are essential in Plasmodium berghei but ITPase and NDH are dispensable

机译：疟疾寄生虫中DNA房间清洁酶的功能遗传学评价：DUTPASE和AP4AH在苯乙烯疟原下是必不可少的，但ITPase和NDH可分配
- 作者：Kumar Hirdesh;Kehrer Jessica;Singer Mirko;Reinig Miriam;Santos Jorge M.;Mair Gunnar R.;Frischknecht Friedrich
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第6期
- Malaria;
- house-cleaning enzymes;
- drug targets;
- dUTPase;
- ITPase;
- NuDiX;
- nucleoside triphosphate pyrophosphohydrolase;
70.Emerging role of SETDB1 as a therapeutic target

机译：SetdB1作为治疗目标的新兴作用
- 作者：Karanth Archana Venkataramana;Maniswami Radhika Radha;Prashanth Seema;Govindaraj Hemalatha;Padmavathy Ramya;Jegatheesan Sooriya Kumar;Mullangi Ramesh;Rajagopal Sriram
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第6期
- Cancer;
- DZNep;
- gene silencing;
- H3K9 trimethylation;
- mithramycin;
- SETDB1;
71.Restoring BMPRII functions in pulmonary arterial hypertension: opportunities, challenges and limitations

机译：在肺动脉高压下恢复BMPRII功能：机会，挑战和限制
- 作者：Guignabert Christophe;Bailly Sabine;Humbert Marc
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第6期
- Pulmonary hypertension;
- genetic predisposition;
- vasculature;
- BMP receptor activation;
- BMP;
72.COPD: preclinical models and emerging therapeutic targets

机译：COPD：临床前模型和新兴治疗目标
- 作者：Esther Barreiro;Xuejie Wang;Jun Tang
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第12期
- Animal models;
- cigarette smoke exposure;
- COPD;
- lung regeneration potential;
- mesenchymal stromal cells;
- surfactant protein-D;
73.VEGF as a potential target in lung cancer

机译：VEGF作为肺癌的潜在目标
- 作者：Frezzetti Daniela;Gallo Marianna;Maiello Monica R.;DAlessio Amelia;Esposito Claudia;Chicchinelli Nicoletta;Normanno Nicola;De Luca Antonella
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第12期
- Vascular endothelial growth factor;
- lung cancer;
- anti-VEGF therapies;
- tumor cells;
74.Triggering receptor expressed on myeloid cells 2 (TREM2): a potential therapeutic target for Alzheimer disease?

机译：在骨髓细胞2（Trem2）上表达的触发受体：Alzheimer疾病的潜在治疗靶标？
- 作者：Yuetiva Deming;Zeran Li;Bruno A. Benitez;Carlos Cruchaga
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第12期
- TREM2;
- Alzheimer disease;
- cerebrospinal fluid;
- genetic association;
- microglia;
75.Animal models suggest the TRIP8b-HCN interaction is a therapeutic target for major depressive disorder

机译：动物模型表明TRIP8B-HCN互动是主要抑郁症的治疗靶标
- 作者：Lyman Kyle A.;Han Ye;Chetkovich Dane M.
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第6期
- HCN;
- TRIP8b;
- depression;
- Pex5;
- ion channel;
76.Implications of Bcl-2 and its interplay with other molecules and signaling pathways in prostate cancer progression

机译：Bcl-2的影响及其与其他分子和信号通路在前列腺癌进展中的相互作用
- 作者：Kim Ju-Ha;Lee Hyemin;Shin Eun Ah;Kim Dong Hee;Choi Jhin Baek;Kim Sung-Hoon
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第12期
- BCL-2;
- androgen;
- prostate cancer;
- microRNAs;
- PTEN;
- AKT;
77.Not the comfy chair! Cancer drugs that act against multiple active sites

机译：不是舒适的椅子！癌症药物对多个活性位点起作用
- 作者：Laurence Booth;Andrew Poklepovic;Paul Dent
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第12期
- Autophagy;
- apoptosis;
- chaperone;
- drug;
- endoplasmic reticulum;
- ERK;
- histone deacetylase;
- kinase;
- MAP kinase;
- neratinib;
- off-target effect;
- pazopanib;
- pemetrexed;
- receptor tyrosine kinase;
- sorafenib;
- survival signaling;
78.The 70-kDa heat shock protein (Hsp70) as a therapeutic target for stroke?

机译：70-KDA热休克蛋白（HSP70）作为中风的治疗靶标？
- 作者：Jong Youl Kim;Yeonseung Han;Jong Eun Lee
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第6期
79.The potential of signal peptide peptidase as a therapeutic target for hepatitis C

机译：信号肽肽酶作为丙型肝炎治疗靶标的潜力
- 作者：Moriishi Kohji
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第12期
- HCV;
- signal peptide peptidase;
- hepatitis C;
- DAA;
80.Targeting connexin hemichannels to control the inflammasome: the correlation between connexin43 and NLRP3 expression in chronic eye disease

机译：靶向Connexin血管箱以控制炎症：Connexin43和NLRP3在慢性眼病中的相关性
- 作者：Odunayo O. Mugisho;llva D. Rupenthal;Francois Paquet-Dur;Monica L Acosta;Colin R. Green
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第12期
- Inflammasome;
- ocular disease;
- chronic disease;
- connexin hemichannel;
- connexin43;
- NLRP3 activation;
- inflammatory cytokine release;
81.Kinin B1 receptors as a therapeutic target for inflammation?

机译：Kinin B1受体作为炎症的治疗靶标？
- 作者：Fatimunnisa Qadri;Michael Bader
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第6期
82.Cellular and molecular mechanisms driving neuropathic pain: recent advancements and challenges?

机译：细胞和分子机制驾驶神经病疼痛：最近的进步和挑战？
- 作者：Valencia Fernes;Dilip Sharma;Shivani Vaidya
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第6期
83.Emerging therapeutic targets for treatment of leishmaniasis

机译：新出现的治疗目标用于治疗Leishmaniaisis
- 作者：Sundar Shyam;Singh Bhawana
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第6期
- Leishmaniasis;
- drug discovery;
- drug targets;
- mitochondria;
- metabolic pathways;
84.Interplay between the key proteins of serotonin system in SSRI antidepressants efficacy?

机译：SSRI抗抑郁剂疗效中血清素系统的关键蛋白质之间的相互作用？
- 作者：Alexer V. Kulikov;Raul R. Gainetdinov;Evgeni Ponimaskin
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第6期
85.Emerging therapeutic targets in the short QT syndrome?

机译：在短QT综合征中出现治疗靶标？
- 作者：Jules C Hancox;Dominic G Whittaker;Chunyun Du
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第6期
86.Update on Fc receptor-like (FCRL) family: new immunoregulatory players in health and diseases

机译：关于FC受体样（FCRL）家族的更新：健康和疾病的新免疫调节运动员
- 作者：Rostamzadeh Davood;Kazemi Tohid;Amirghofran Zahra;Shabani Mahdi
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第6期
- FCRL;
- B-cell;
- malignancies;
- autoimmune diseases;
- infectious diseases;
- signaling pathways;
- immunotherapy approaches;
87.Recent progress in therapeutic strategies for microglia-mediated neuroinflammation in neuropathologies

机译：神经病理学中微血管介导的神经肾性炎症治疗策略的最新进展
- 作者：Neelima Gupta;Sukanya Shyamasundar;Radhika Patnala;Aparna Karthikeyan;Thiruma V. Arumugam;Eng-Ang Ling;S. Thameem Dheen
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第12期
- Microglia;
- activation;
- neuroinflammation;
- neurodegeneration;
- therapeutics;
88.The emergence of TNIK as a therapeutic target for colorectal cancer

机译：TNIK作为结直肠癌治疗靶标的出现
- 作者：Masuda Mari;Yamada Tesshi
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第6期
- Wnt signaling;
- colorectal cancer;
- TNIK;
- cancer stem cell;
89.The therapeutic potential of targeting ABC transporters to combat multi-drug resistance

机译：靶向ABC转运蛋白的治疗潜力，以打击多药抗性
- 作者：Bugde Piyush;Biswas Riya;Merien Fabrice;Lu Jun;Liu Dong-Xu;Chen Mingwei;Zhou Shufeng;Li Yan
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第6期
- ABC transporter;
- pharmacokinetics;
- multidrug resistance;
- cancer;
- nanotechnology;
90.Implications of Toll-like receptors in Ebola infection

机译：Toll样受体在埃博拉感染中的影响
- 作者：Saghazadeh Amene;Rezaei Nima
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第6期
- Ebola virus;
- interferon;
- Toll-like receptor;
91.Targeted therapy to annihilate the immune-evading phenotype in cancer evolution

机译：有针对性的疗法将免疫疏忽癌症进化中的免疫表型灭绝
- 作者：Ariel Fernez
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第12期
- Immunotherapy;
- PD-1 checkpoint blockade;
- DNA mismatch repair;
- phosphoinositide 3-kinase;
- PI3K isoforms;
- immunoediting;
- immune evasion;
- natural selection;
92.Fibrinogen-like protein 2: a potential molecular target for glioblastoma treatment

机译：纤维蛋白原蛋白2：胶质母细胞瘤治疗的潜在分子靶标
- 作者：Rajan Patel;Jeffrey I. Traylor;Khatri Latha;Amy B. Heimberger;Shulin Li;Ganesh Rao
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第12期
- FGL2;
- glioblastoma multiforme;
- low grade glioma;
- progression;
93.The MAP kinase-interacting kinases (MNKs) as targets in oncology

机译：地图激酶 - 相互作用的激酶（MNK）作为肿瘤学的靶标
- 作者：Xie Jianling;Merrett James E.;Jensen Kirk B.;Proud Christopher G.
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第6期
- Cancer;
- eIF4E;
- metastasis;
- MNKs;
- mRNA translation;
- oncology;
- transformation;
94.Therapeutic potential of enhancer of zeste homolog 2 in autoimmune diseases

机译：自身免疫疾病中Zeste同源物2增强子的治疗潜力
- 作者：Yue-Xin Yang;Hui-Hui Shen;Fan Cao;Liang-Yu Xie;Guang-Lin Zhu;Napoleon Bellua Sam;De-Guang Wang;Hai-Feng Pan
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第12期
- EZH2;
- autoimmune disease;
- epigenetic modifications;
- immunological dysfunction;
- therapeutic potential;
95.Sleep disturbances and severe stress as glial activators: key targets for treating central sensitization in chronic pain patients?

机译：睡眠障碍和严重应力作为胶质激活因子：治疗慢性疼痛患者中央致敏的关键目标？
- 作者：Nijs Jo;Loggia Marco L.;Polli Andrea;Moens Maarten;Huysmans Eva;Goudman Lisa;Meeus Mira;Vanderweeen Luc;Ickmans Kelly;Clauw Daniel
- 期刊名称：《Expert opinion on therapeutic targets》 | 2017年第12期
- Pain;
- fibromyalgia;
- low back pain;
- sleep;
- stress;
- neuroinflammation;
96.Evolution of GAPDH as a druggable target of tumor glycolysis??

机译：GAPDH作为肿瘤糖溶解的可毒靶的演变??
- 作者：Shanmugasundaram Ganapathy-Kanniappan
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第6期
97.AdipoRs- a potential therapeutic target for fibrotic disorders

机译：adipors-纤维化疾病的潜在治疗靶标
- 作者：Ma Lingman;Li Xuanyi;Bai Zhaoshi;Lin Xinhao;Lin Kejiang
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第6期
98.Neovascularization: an attractive but tricky target in thyroid cancer

机译：新生血管化：在甲状腺癌中有吸引力但棘手的靶标
- 作者：Jason Tasoulas;Gerasimos Tsourouflis;Stamatios Theocharis
- 期刊名称：《Expert opinion on therapeutic targets》 | 2018年第12期
- Angiogenesis;
- neovascularization;
- targeted therapy;
- thyroid cancer;
- tyrosine kinase receptor inhibitors;
- vascular mimicry;
- vasculogenesis;
99.Aberrant lipid metabolism as a therapeutic target in liver cancer

机译：异常的脂质代谢作为肝癌治疗靶标
- 作者：Pope Evans D. III;Kimbrough Erinmarie O.;Vemireddy Lalitha Padmanabha;Surapaneni Phani Keerthi;Copland John A. III;Mody Kabir
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第6期
- Fatty acid;
- hepatocellular carcinoma;
- liver cancer;
- lipids;
- lipid metabolism;
- stearoyl co-A desaturase;
- SCD1;
100.Diabetic nephropathy: an insight into molecular mechanisms and emerging therapies

机译：糖尿病肾病：深入了解分子机制和新疗法
- 作者：Annabelle M. Warren;Soren T. Knudsen;Mark E. Cooper
- 期刊名称：《Expert opinion on therapeutic targets》 | 2019年第12期
- Diabetic kidney disease;
- diabetic nephropathy;
- diabetic complications;
- prevention;
- therapeutic targets;
- renoprotection;

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