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首页> 外文期刊>Expert opinion on therapeutic targets >Triggering receptor expressed on myeloid cells 2 (TREM2): a potential therapeutic target for Alzheimer disease?
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Triggering receptor expressed on myeloid cells 2 (TREM2): a potential therapeutic target for Alzheimer disease?

机译：在骨髓细胞2（Trem2）上表达的触发受体：Alzheimer疾病的潜在治疗靶标？

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Introduction: There are currently no effective therapeutics for Alzheimer disease (AD). Clinical trials targeting amyloid beta thus far have shown very little benefit and only in the earliest stages of disease. These limitations have driven research to identify alternative therapeutic targets, one of the most promising is the triggering receptor expressed on myeloid cells 2 (TREM2). Areas covered: Here, we review the literature to-date and discuss the potentials and pitfalls for targeting TREM2 as a potential therapeutic for AD. We focus on research in animal and cell models for AD and central nervous system injury models which may help in understanding the role of TREM2 in disease. Expert opinion: Studies suggest TREM2 plays a key role in AD pathology; however, results have been conflicting about whether TREM2 is beneficial or harmful. More research is necessary before designing TREM2-targeting therapies. Successful therapeutics will most likely be administered early in disease.
机译：简介：目前没有有效的阿尔茨海默病（AD）治疗疗法。 迄今为止靶向淀粉样蛋白β的临床试验表明很少有益于疾病的最早阶段。 这些限制已经驱动了研究以识别替代治疗靶标的，最有希望的是在骨髓细胞2（Trem2）上表达的触发受体之一。 所涵盖的区域：在这里，我们审查了文献及时的文献，并讨论了针对TREM2的潜在和陷阱作为广告的潜在治疗方法。 我们专注于AD和中枢神经系统损伤模型的动物和细胞模型的研究，这可能有助于了解Trem2在疾病中的作用。 专家意见：研究表明Trem2在广告病理学中发挥着关键作用; 然而，结果一直矛盾的Trem2是有益或有害的。 在设计Trem2靶向疗法之前，需要进行更多的研究。 成功的治疗方法很可能会在疾病早期给药。

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