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Triggering receptor expressed on myeloid cells 2 (TREM2): a potential therapeutic target for Alzheimer disease?

机译：在髓样细胞2（TREM2）上表达的触发受体：阿尔茨海默氏病的潜在治疗靶点吗？

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Introduction:There are currently no effective therapeutics for Alzheimer disease (AD). Clinical trials targeting amyloid beta thus far have shown very little benefit and only in the earliest stages of disease. These limitations have driven research to identify alternative therapeutic targets, one of the most promising is the triggering receptor expressed on myeloid cells 2 (TREM2).

机译：简介：目前尚无有效的治疗阿尔茨海默氏病（AD）的药物。迄今为止，针对淀粉样蛋白β的临床试验显示出很小的益处，并且仅在疾病的早期阶段。这些局限性驱使人们进行研究，以确定其他治疗靶标，其中最有前途的方法之一是在髓样细胞2（TREM2）上表达的触发受体。

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期刊名称 other
作者
Yuetiva Deming; Zeran Li; Bruno A. Benitez; Carlos Cruchaga;
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作者单位

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年(卷),期 -1(22),7
年度 -1
页码 587–598
总页数 24
原文格式 PDF
正文语种
中图分类
关键词
TREM2 Alzheimer disease cerebrospinal fluid genetic association microglia;

机译：TREM2;阿尔茨海默氏病;脑脊液;遗传关联;小胶质细胞;

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1. Triggering receptor expressed on myeloid cells 2 (TREM2): a potential therapeutic target for Alzheimer disease? [J] . Yuetiva Deming, Zeran Li, Bruno A. Benitez, Expert opinion on therapeutic targets . 2018,第7a12期

机译：在骨髓细胞2（Trem2）上表达的触发受体：Alzheimer疾病的潜在治疗靶标？
2. Triggering receptor expressed on myeloid cells and 5'adenosine monophosphate-activated protein kinase in the inflammatory response: a potential therapeutic target [J] . Thankam Finosh G., Dilisio Matthew F., Dougherty Kaitlin A., Expert review of clinical immunology . 2016,第11期

机译：炎症反应中髓样细胞和5'腺苷单磷酸激活的蛋白激酶表达的触发受体：潜在的治疗靶点
3. Triggering receptor expressed on myeloid cells type 1 as a potential therapeutic target in sepsis. [J] . Palazzo SJ, Simpson T, Schnapp LM Dimensions of critical care nursing: DCCN . 2012,第1期

机译：在1型骨髓细胞上表达的触发受体是脓毒症的潜在治疗靶标。
4. Triggering receptor expressed on myeloid cells (TREM)-1 expression on polymorphonuclear neutrophils enhanced the bacterial clearance from the nose in synergy with TLR4 [C] . Moriyama M., Hirano T., Kodama S., Extraordinary International Symposium on Recent Advances in Otitis Media . 2014

机译：在多核核心子粒细胞上表达的触发受体（TREM）-1表达增强了与TLR4的协同作用中鼻子的细菌间隙
5. Integration of Alzheimer's Disease Genetics, Myeloid Cell Genomics and Gene Regulatory Networks Reveals Novel Disease Mechanisms, Drug Targets and Candidate Therapeutics [D] . Novikova, Gloriia. 2021

机译：阿尔茨海默病遗传学，骨髓细胞基因组学和基因监管网络的整合揭示了新型疾病机制，药物目标和候选治疗方法
6. Triggering Receptor Expressed on Myeloid Cells and 5′Adenosine Monophosphate-activated Protein kinase in the Inflammatory Response: A Potential Therapeutic Target [O] . Finosh G Thankam, Matthew F. Dilisio, Kaitlin A. Dougherty, -1

机译：炎症细胞中髓样细胞和5腺苷单磷酸激活的蛋白激酶表达的触发受体：潜在的治疗靶点
7. Triggering receptor expressed on myeloid cells 2 (TREM2): a potential therapeutic target for Alzheimer disease? [O] . Yuetiva Deming, Zeran Li, Bruno A. Benitez, 2018

机译：在骨髓细胞2（Trem2）上表达的触发受体：阿尔茨海默病的潜在治疗靶标？

Triggering receptor expressed on myeloid cells 2 (TREM2): a potential therapeutic target for Alzheimer disease?

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