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COPD: preclinical models and emerging therapeutic targets

机译：COPD：临床前模型和新兴治疗目标

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ABSTRACT Introduction: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Preclinical models of COPD have recently been developed. In those models, COPD/emphysema has been commonly induced using different toxic agents such as elastase, proteo-lytic enzymes and chronic exposure to cigarette smoke (CS). Areas covered: The most relevant features of preclinical models of COPD, namely chronic exposure to CS and other agents (proteases and microorganisms), cardiovascular effects, surfactant protein-D, airway remodeling and inflammation, lung regeneration potential and mesenchymal stromal cell therapy are described. The most relevant publications on the topic of interest were selected from Pubmed. Expert opinion: Preclinical models of COPD are key for understanding the underlying biology and pathophysiology of the disease and for the discovery of therapeutic targets. Enhanced biological insights will help discover therapeutic targets for the treatment of COPD. This will enable health caregivers and doctors to improve treatment where a more holistic approach will be used. This will benefit the patients and society because the use of resources should be significantly lowered.
机译：摘要介绍：慢性阻塞性肺病（COPD）是全世界发病率和死亡率的主要原因。最近开发了COPD的临床前模型。在这些模型中，COPD /肺气肿通常使用不同的毒性药物，例如弹性蛋白酶，蛋白质溶解酶和慢性暴露于香烟烟雾（CS）。涵盖了地区：COPD临床前模型的最相关特征，即慢性接触Cs和其他药剂（蛋白酶和微生物），心血管作用，表面活性剂蛋白-D，气道重塑和炎症，肺再生电位和间充质基质细胞疗法。关于兴趣主题的最相关的出版物是选自Pubmed的。专家意见：COPD的临界模型是了解疾病的潜在生物学和病理生理学以及发现治疗目标的关键。增强的生物洞察将有助于发现治疗治疗的治疗目标。这将使健康护理人员和医生改善将使用更全面的方法的治疗。这将使患者和社会受益，因为应大大降低资源。

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