Targeting pancreatic expressed PAX genes for the treatment of diabetes mellitus and pancreatic neuroendocrine tumors

Martin-Montalvo Alejandro; Lorenzo Petra I.; Lopez-Noriega Livia; Gauthier Benoit R.

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Targeting pancreatic expressed PAX genes for the treatment of diabetes mellitus and pancreatic neuroendocrine tumors

机译：针对胰腺表达的PAX基因用于治疗糖尿病和胰腺神经内分泌肿瘤

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Introduction: Four members of the PAX family, PAX2, PAX4, PAX6 and PAX8 are known to be expressed in the pancreas. Accumulated evidences indicate that several pancreatic expressed PAX genes play a significant role in pancreatic development/functionality and alterations in these genes are involved in the pathogenesis of pancreatic diseases.

机译：简介：已知在胰腺中表达PAX系列，PAX2，PAX4，PAX6和PAX8的四个成员。积累的证据表明，几种胰腺表达的PAX基因在胰腺发育/功能中发挥着重要作用，并且这些基因的改变参与了胰腺疾病的发病机制。

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《Expert opinion on therapeutic targets》 |2017年第6期|共13页
作者
Martin-Montalvo Alejandro; Lorenzo Petra I.; Lopez-Noriega Livia; Gauthier Benoit R.;
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作者单位

CABIMER Andalusian Ctr Mol Biol &

Regenerat Med PIDRU LAB Dept Stem Cells Ave Americo Vespucio;

CABIMER Andalusian Ctr Mol Biol &

Regenerat Med PIDRU LAB Dept Stem Cells Ave Americo Vespucio;

CABIMER Andalusian Ctr Mol Biol &

Regenerat Med PIDRU LAB Dept Stem Cells Ave Americo Vespucio;

CABIMER Andalusian Ctr Mol Biol &

Regenerat Med PIDRU LAB Dept Stem Cells Ave Americo Vespucio;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Diabetes mellitus; pancreatic neuroendocrine tumors; PAX genes; PAX2; PAX4; PAX6; PAX8;

机译：糖尿病;胰腺神经内分泌肿瘤;pax基因;pax2;pax4;pax8;

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专利

1. Targeting pancreatic expressed PAX genes for the treatment of diabetes mellitus and pancreatic neuroendocrine tumors [J] . Martin-Montalvo Alejandro, Lorenzo Petra I., Lopez-Noriega Livia, Expert opinion on therapeutic targets . 2017,第1a6期

机译：针对胰腺表达的PAX基因用于治疗糖尿病和胰腺神经内分泌肿瘤
2. PAX8 is expressed in pancreatic well-differentiated neuroendocrine tumors and in extrapancreatic poorly differentiated neuroendocrine carcinomas in fine-needle aspiration biopsy specimens. [J] . Haynes CM, Sangoi AR, Pai RK Cancer: A Journal of the American Cancer Society . 2011,第3期

机译：PAX8在细针穿刺活检标本中的胰腺高分化神经内分泌肿瘤和胰腺外低分化神经内分泌癌中表达。
3. Elevated pancreatic polypeptide levels in pancreatic neuroendocrine tumors and diabetes mellitus: Causation or association? [J] . MaxwellJ.E., ODorisioT.M., BellizziA.M., Pancreas . 2014,第4期

机译：胰腺神经内分泌肿瘤和糖尿病中胰腺多肽水平升高：因果还是关联？
4. Bio-distribution of Near Infrared Imaging Agent Loaded Targeted Drug Nanoparticle Carriers in Highly Fibrotic Pancreatic Tumor Determined Using Multiphoton and Harmonic Generation Imaging [C] . Thomas Abraham, Gary A. Clawson, Samuel S. Linton, International Symposium on Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues . 2018

机译：近红外成像剂的生物分布在使用多选和谐波生成成像中测定的高纤维化胰腺肿瘤中的靶向药物纳米粒子载体
5. Sub-Clonal Analysis of Tumor Grade and Treatment-Resistant Pancreatic Neuroendocrine Tumors (pNET) at Multiple Disease Time Points [D] . Bahadur, Nadia S.P. 2020

机译：多种疾病时分肿瘤级和治疗抗性胰腺神经内分泌肿瘤（PNET）的亚克隆分析
6. Elevated Pancreatic Polypeptide Levels in Pancreatic Neuroendocrine Tumors and Diabetes Mellitus: Causation or Association? [O] . Jessica Maxwell, Thomas M. O’Dorisio, Andrew M. Bellizzi, -1

机译：胰腺神经内分泌肿瘤和糖尿病中胰腺多肽水平升高：是因果还是关联？
7. PAX8 expression reliably distinguishes pancreatic well-differentiated neuroendocrine tumors from ileal and pulmonary well-differentiated neuroendocrine tumors and pancreatic acinar cell carcinoma [O] . Ankur R Sangoi, Robert S Ohgami, Rish K Pai, 2010

机译：PAX8表达可靠地将胰腺良好分化的神经内分泌肿瘤与髂骨和肺部良好分化的神经内分泌肿瘤和胰腺腺体细胞癌中的胰腺良好分化的神经内分泌肿瘤可靠地区分

Targeting pancreatic expressed PAX genes for the treatment of diabetes mellitus and pancreatic neuroendocrine tumors

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