• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Expert opinion on therapeutic targets >The therapeutic potential of targeting ABC transporters to combat multi-drug resistance
【24h】

The therapeutic potential of targeting ABC transporters to combat multi-drug resistance

机译：靶向ABC转运蛋白的治疗潜力，以打击多药抗性

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Introduction: Most disseminated cancers remain fatal despite the availability of a variety of conventional and novel treatments including surgery, chemotherapy, radiotherapy, immunotherapy, and biologically targeted therapy. A major factor responsible for the failure of chemotherapy in the treatment of cancer is the development of multidrug resistance (MDR). The overexpression of various ABC transporters in cancer cells can efficiently remove the anticancer drug from the cell, thus causing the drug to lose its effect.Areas covered: In this review, we summarised the ongoing research related to the mechanism, function, and regulation of ABC transporters. We integrated our current knowledge at different levels from molecular biology to clinical trials. We also discussed potential therapeutic strategies of targeting ABC transporters to reverse MDR in cancer cells.Expert opinion: Involvement of various ABC transporters to cancer MDR lays the foundation for developing tailored therapies that can overcome MDR. An ideal MDR reversal agent should have broad-spectrum ABC-transporter inhibitory activity, be potent, have good pharmacokinetics, have no trans-stimulation effects, and have low or no toxicity. Alternatively, nanotechnology-based drug delivery systems containing both the cytotoxic drug and reversing agent may represent a useful approach to reversing MDR with minimal off-target toxicity.
机译：介绍：尽管提供了各种常规和新的治疗，但包括手术，化疗，放疗，免疫疗法和生物靶向治疗等各种传统和新的治疗，但最多传播的癌症仍然致命。负责化疗失败治疗癌症的主要因素是多药抗性（MDR）的发展。癌细胞中各种ABC转运蛋白的过度表达可以有效地从细胞中取出抗癌药物，从而导致药物失去其效果。覆盖：在本综述中，我们总结了与机制，功能和调节有关的持续研究ABC运输车。我们将目前的知识与分子生物学的不同水平纳入临床试验。我们还讨论了靶向ABC转运蛋白的潜在治疗策略，以逆转癌细胞中的MDR.Expert意见：各种ABC运输扣对癌症MDR的参与为发展MDR制定量身定制的疗法奠定了基础。理想的MDR逆转剂应具有广谱ABC-Transporter抑制活性，具有良好的药代动力学，具有良好的药代动力学，没有反式刺激作用，并且具有低或无毒性。或者，含有细胞毒性药物和逆转剂的基于纳米技术的药物递送系统可以代表逆转MDR的有用方法，其具有最小的偏离靶向毒性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号