Mouse ATP-Binding Cassette (ABC) Transporters Conferring Multi-Drug Resistance

Li Shuaizhang; Zhang Wen; Yin Xuejiao; Xing Shilai; Xie Heidi Qunhui; Cao Zhengyu; Zhao Bin

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Mouse ATP-Binding Cassette (ABC) Transporters Conferring Multi-Drug Resistance

机译：赋予多药耐药性的小鼠ATP结合盒（ABC）转运蛋白

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The ABC (ATP-binding cassette) transporter is one of the largest and most ancient protein families with members functioning from protozoa to human. The resistance of cancer and tumor cells to anticancer drugs is due to the over-expression of some ABC transporters, which may finally lead to chemotherapy failure. The mouse ABC transporters are classified into seven subfamilies by phylogenetic analysis. The mouse ABC transporter gene, alias, chromosomal location and function have been determined. Within the ABC super-family, the MDR transporters (Abcb1, Abcc1, Abcg2) in mouse models have been proved to be valuable to investigate the biochemistry and physiological functions. This review concentrates on the multidrug resistance of mouse ABC transporters in cancer and tumor cells.

机译：ABC（ATP结合盒）转运蛋白是最大和最古老的蛋白质家族之一，成员的功能从原生动物到人类。癌症和肿瘤细胞对抗癌药物的耐药性是由于某些ABC转运蛋白的过表达引起的，最终可能导致化疗失败。小鼠ABC转运蛋白通过系统发育分析被分为七个亚科。小鼠ABC转运蛋白基因，别名，染色体位置和功能已确定。在ABC超家族中，已证明小鼠模型中的MDR转运蛋白（Abcb1，Abcc1，Abcg2）对于研究生物化学和生理功能具有重要价值。这篇综述集中于小鼠ABC转运蛋白在癌细胞和肿瘤细胞中的多药耐药性。

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来源
《Anti-cancer agents in medicinal chemistry》 |2015年第4期|共10页
作者
Li Shuaizhang; Zhang Wen; Yin Xuejiao; Xing Shilai; Xie Heidi Qunhui; Cao Zhengyu; Zhao Bin;
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正文语种 eng
中图分类药品;
关键词
ATP-binding cassette (ABC) transporter; cancer; inhibitors; multi-drug resistance; substrate;

机译：ATP结合盒（ABC）转运蛋白;癌症;抑制剂;多药耐药性;底物;

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专利

1. Mouse ATP-Binding Cassette (ABC) Transporters Conferring Multi-Drug Resistance [J] . Li Shuaizhang, Zhang Wen, Yin Xuejiao, Anti-cancer agents in medicinal chemistry . 2015,第4期

机译：赋予多药耐药性的小鼠ATP结合盒（ABC）转运蛋白
2. Human ATP-Binding Cassette transporters ABCB1 and ABCG2 confer resistance to CUDC-101, a multi-acting inhibitor of histone deacetylase, epidermal growth factor receptor and human epidermal growth factor receptor 2 [J] . Wu Chung-Pu, Hsiao Sung-Han, Su Ching-Ya, Biochemical Pharmacology . 2014,第4期

机译：人ATP结合盒式转运蛋白ABCB1和ABCG2赋予对CUDC-101的抗性，CUDC-101是组蛋白脱乙酰基酶，表皮生长因子受体和人表皮生长因子受体2的多效抑制剂
3. Human ATP-Binding Cassette Transporter. ABCG2 Confers Resistance to CUDC-907, a Dual Inhibitor of Histone Deacetylase and Phosphatidylinositol 3-Kinase [J] . Wu Chung-Pu, Hsieh Ya-Ju, Hsiao Sung-Han, Molecular pharmaceutics . 2016,第3期

机译：人ATP结合盒式转运蛋白。 ABCG2赋予对组蛋白脱乙酰基酶和磷脂酰肌醇3-激酶的双重抑制剂CUDC-907的抗性。
4. ON-CHIP SINGLE VESICLE ANALYSES OF ATP-BINDING CASSETTE (ABC) TRANSPORTERS [C] . H. Sasaki, R. Kawano, T. Osaki, International Conference on Miniaturized Systems for Chemistry and Life Sciences . 2011

机译：ATP结合盒（ABC）转运蛋白的片上单囊泡分析
5. The role of the ATP-binding cassette (ABC) transporter ABCC5a in hindgut invagination of sea urchin embryos [D] . Shipp, Lauren Elizabeth 2015

机译：ATP结合盒（ABC）转运蛋白ABCC5a在海胆胚胎后肠内陷中的作用
6. Drug Resistance Is Conferred on the Model Yeast Saccharomyces cerevisiae by Expression of Full-Length Melanoma-AssociatedHuman ATP-Binding Cassette Transporter ABCB5 [O] . MikhailV. Keniya, ⊥, Ann R. Holmes, -1

机译：通过表达全长黑色素瘤相关的模型酵母啤酒酵母赋予耐药性。人ATP结合盒式转运蛋白ABCB5
7. The Candida albicans Cdr2p ATP-binding cassette (ABC) transporter confers resistance to caspofungin [O] . Manuela Schuetzer-Muehlbauer, Birgit Willinger, Gerd Krapf, 2003

机译：Candida albicans CDR2P ATP结合盒（ABC）转运蛋白赋予Caspofungin的抗性

Mouse ATP-Binding Cassette (ABC) Transporters Conferring Multi-Drug Resistance

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