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首页> 外文期刊>Expert opinion on therapeutic targets >Galectin-3: is this member of a large family of multifunctional lectins (already) a therapeutic target?
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Galectin-3: is this member of a large family of multifunctional lectins (already) a therapeutic target?

机译：Galectin-3：这是一家大型多功能凝集素（已经）治疗目标的成员吗？

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ABSTRACT Introduction: The discoveries that sugars are a highly versatile platform to generate biochemical messages and that glycan-specific receptors (lectins) are a link between these signals and their bioactivity explain the interest in endogenous lectins such as galectins. Their analysis is a highly dynamic field. It is often referred to as being promising for innovative drug design. Area covered: We present a primer to the concept of the sugar code by glycan-(ga)lectin recognition, followed by a survey on galectin-3 (considering common and distinct features within this family of multifunctional proteins expressed at various cellular sites and cell types). Finally, we discuss strategies capable of blocking (ga)lectin activity, with an eye on current challenges and inherent obstacles. Expert opinion: The emerging broad profile of homeostatic and pathophysiological bioactivities stimulates further efforts to explore galectin (Gal-3) functionality, alone and then in mixtures. Like thoroughly assessing the pros and cons of blocking approaches for a multifunctional protein active at different sites, identifying a clinical situation, in which the galectin is essential in the disease process, will be critical.
机译：摘要介绍：糖是糖是一种高度通用的平台，以产生生化信息，并且糖类特异性受体（凝集素）是这些信号与其生物活性之间的联系，解释了内源性凝集素如半乳素的兴趣。他们的分析是一个高度动态的领域。它通常被称为对创新的药物设计有前途。面积覆盖：我们向甘草（GA）凝集素识别提出了糖代码概念的底漆，其次是Galectin-3的调查（考虑在各种细胞位点和细胞中表达的多功能蛋白质中的共同和不同的特征类型）。最后，我们讨论了能够阻断（Ga）凝集活性的策略，目前有目前的挑战和固有的障碍。专家意见：新兴广泛的稳态和病理生理生物活化性刺激了探索半乳糖型（GAL-3）功能，单独促进半抗菌素（GAL-3）功能的努力。类似于彻底评估在不同部位的多功能蛋白活性的封闭方法的优缺点，鉴定临床情况，其中半乳蛋白在疾病过程中是必不可少的，这将是至关重要的。

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