Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport

Zhang Jinwei; Karimy Jason K.; Delpire Eric; Kahle Kristopher T.

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Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport

机译：椎骨上皮运输障碍症中Phak激酶的药理靶向

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Introduction: The mammalian SPS1-related proline/alanine-rich serine-threonine kinase SPAK (STK39) modulates ion transport across and between epithelial cells in response to environmental stimuli such osmotic stress and inflammation. Research over the last decade has established a central role for SPAK in the regulation of ion and water transport in the distal nephron, colonic crypts, and pancreatic ducts, and has implicated deregulated SPAK signaling in NaCl-sensitive hypertension, ulcerative colitis and Crohn's disease, and cystic fibrosis.

机译：简介：哺乳动物SPS1相关的脯氨酸/富含丙氨酸丝氨酸苏氨酸激酶spak（STK39）在响应于环境刺激这种渗透压和炎症的环境刺激和上皮细胞之间调节离子输送。过去十年的研究在远端肾，结肠隐窝和胰管中的离子和水运输调节中建立了稳定的作用，并且在NaCl敏感的高血压，溃疡性结肠炎和克罗恩病中具有牵连的令人失调的Spak信号传导。和囊性纤维化。

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来源
《Expert opinion on therapeutic targets》 |2017年第12期|共10页
作者
Zhang Jinwei; Karimy Jason K.; Delpire Eric; Kahle Kristopher T.;
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作者单位

Univ Exeter Med Sch Inst Biomed &

Clin Sci Hatherly Lab Exeter Devon England;

Yale Sch Med Dept Neurosurg New Haven CT USA;

Vanderbilt Univ Sch Med Dept Anesthesiol Nashville TN 37212 USA;

Yale Sch Med Dept Neurosurg New Haven CT 06510 USA;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Blood pressure regulation; cation-chloride cotransporters (CCCs); ion homeostasis; kinase inhibitors; signal transduction; SPAK phosphorylation;

机译：血压调节;阳离子 - 氯化物分类剂（CCC）;离子稳态;激酶抑制剂;信号转导;祛痰磷酸化;

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1. Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport [J] . Zhang Jinwei, Karimy Jason K., Delpire Eric, Expert opinion on therapeutic targets . 2017,第7a12期

机译：椎骨上皮运输障碍症中Phak激酶的药理靶向
2. FBXW7 regulates epithelial barrier impairment in human bronchial epithelial cells in vitro by targeting apoptosis signal-regulating kinase1 via the p38 pathway [J] . JINGRONG SONG, JUAN KANG, WEI LV, Biocell . 2021,第3期

机译：通过P38途径靶向细胞凋亡信号调节激酶1，FBXW7在体外调节人支气管上皮细胞的上皮屏障损伤
3. Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis [J] . Sara I. Cunha, Evangelia Pardali, Midory Thorikay, The Journal of Experomental Medicine . 2010,第1期

机译：激活素受体样激酶1的遗传和药理靶向削弱肿瘤的生长和血管生成。
4. Targeting of kinase inhibitor-LZM conjugates to proximal tubular epithelial cellsfor local treatment of renal fibrosis [C] . Maria E Dolman, Marjan M Fretz, Stefan Harmsen, Annual meeting exposition of the Controlled Release Society . 2009

机译：激酶抑制剂-LZM结合物靶向肾小管上皮细胞以局部治疗肾纤维化
5. Roles of the serine-threonine kinases glycogen synthase kinase-3 beta and protein kinase CK2 in mammary tumorigenesis and epithelial to mesenchymal transition. [D] . Farago, Marganit. 2007

机译：丝氨酸-苏氨酸激酶糖原合酶激酶-3β和蛋白激酶CK2在乳腺肿瘤发生和上皮向间质转化中的作用。
6. Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport [O] . Jinwei Zhang, Jason K. Karimy, Eric Delpire, -1

机译：SPAK激酶在上皮运输障碍中的药理靶向
7. Pharmacological activators of AMP-activated protein kinase have different effects on Na+ transport processes across human lung epithelial cells [O] . Woollhead, A M, Sivagnanasundaram, J, Kalsi, K K, 2009

机译：AMP激活的蛋白激酶的药理激活剂对跨人肺上皮细胞的Na +转运过程有不同的影响

Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport

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