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Sleep disturbances and severe stress as glial activators: key targets for treating central sensitization in chronic pain patients?

机译:睡眠障碍和严重应力作为胶质激活因子:治疗慢性疼痛患者中央致敏的关键目标?

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摘要

Introduction: The mechanism of sensitization of the central nervous system partly explains the chronic pain experience in many patients, but the etiological mechanisms of this central nervous system dysfunction are poorly understood. Recently, an increasing number of studies suggest that aberrant glial activation takes part in the establishment and/or maintenance of central sensitization.
机译:介绍:中枢神经系统的致敏机制部分解释了许多患者的慢性疼痛经验,但这种中枢神经系统功能障碍的病因机制很差。 最近,越来越多的研究表明,异常的胶质激活参与了中央致敏的建立和/或维护。

著录项

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  • 作者单位

    Vrije Univ Brussel Dept Physiotherapy Human Physiol &

    Anat Pain Mot Int Res Grp Brussels Belgium;

    Harvard Med Sch Massachusetts Gen Hosp MGH HST AA Martinos Ctr Biomed Imaging Dept Radiol;

    Vrije Univ Brussel Dept Physiotherapy Human Physiol &

    Anat Pain Mot Int Res Grp Brussels Belgium;

    Univ Hosp Brussels Dept Neurosurg &

    Radiol Brussels Belgium;

    Vrije Univ Brussel Dept Physiotherapy Human Physiol &

    Anat Pain Mot Int Res Grp Brussels Belgium;

    Vrije Univ Brussel Dept Physiotherapy Human Physiol &

    Anat Pain Mot Int Res Grp Brussels Belgium;

    Vrije Univ Brussel Dept Physiotherapy Human Physiol &

    Anat Pain Mot Int Res Grp Brussels Belgium;

    Vrije Univ Brussel Dept Physiotherapy Human Physiol &

    Anat Pain Mot Int Res Grp Brussels Belgium;

    Vrije Univ Brussel Dept Physiotherapy Human Physiol &

    Anat Pain Mot Int Res Grp Brussels Belgium;

    Univ Michigan Chron Pain &

    Fatigue Res Ctr Ann Arbor MI 48109 USA;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药学;
  • 关键词

    Pain; fibromyalgia; low back pain; sleep; stress; neuroinflammation;

    机译:疼痛;纤维肌痛;腰痛;睡眠;压力;神经炎症;

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