GPER-1/GPR30 a novel estrogen receptor sited in the cell membrane: therapeutic coupling to breast cancer

Molina Luis; Figueroa Carlos D.; Bhoola Kanti D.; Ehrenfeld Pamela

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GPER-1/GPR30 a novel estrogen receptor sited in the cell membrane: therapeutic coupling to breast cancer

机译：GPER-1 / GPR30在细胞膜中具有新的雌激素受体：治疗偶联与乳腺癌

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Introduction: Breast cancer is clinically classified as 'estrogen-positive' when at least 1% of cancer cells stain for the estrogen receptor alpha (ER alpha). However, recent research on both basic and clinical aspects of breast cancer suggests that GPER-1 (G protein-coupled estrogen receptor-1) may have an important role in breast cancer.

机译：介绍：当雌激素受体α（ERα）的至少1％的癌细胞染色中，乳腺癌临床归类为“雌激素阳性”。然而，最近关于乳腺癌的基本和临床方面的研究表明，GPER-1（G蛋白偶联雌激素受体-1）可能在乳腺癌中具有重要作用。

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《Expert opinion on therapeutic targets》 |2017年第12期|共12页
作者
Molina Luis; Figueroa Carlos D.; Bhoola Kanti D.; Ehrenfeld Pamela;
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作者单位

Univ Austral Chile Inst Anat Histol &

Pathol Lab Cellular Pathol Casilla 567 Valdivia Chile;

Univ Austral Chile Inst Anat Histol &

Pathol Lab Cellular Pathol Casilla 567 Valdivia Chile;

Univ Austral Chile Inst Anat Histol &

Pathol Lab Cellular Pathol Casilla 567 Valdivia Chile;

Univ Austral Chile Inst Anat Histol &

Pathol Lab Cellular Pathol Casilla 567 Valdivia Chile;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Estrogen receptors; GPER-1; GPR30; breast cancer; tamoxifen; endocrine therapy; signaling pathways;

机译：雌激素受体;GPER-1;GPR30;乳腺癌;Tamoxifen;内分泌治疗;信号通路;

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专利

1. GPER-1/GPR30 a novel estrogen receptor sited in the cell membrane: therapeutic coupling to breast cancer [J] . Molina Luis, Figueroa Carlos D., Bhoola Kanti D., Expert opinion on therapeutic targets . 2017,第7a12期

机译：GPER-1 / GPR30在细胞膜中具有新的雌激素受体：治疗偶联与乳腺癌
2. In Vivo Functions of GPR30/GPER-1, a Membrane Receptor for Estrogen: From Discovery to Functions In Vivo [J] . Yoichi MIZUKAMI Endocrine journal . 2010,第2期

机译：GPR30 / GPER-1（一种雌激素的膜受体）的体内功能：从发现到体内功能
3. In Vivo Functions of GPR30/GPER-1, a Membrane Receptor for Estrogen: From Discovery to Functions In Vivo [J] . Yoichi MIZUKAMI Endocrine journal . 2010,第2期

机译：GPR30 / GPER-1（一种雌激素的膜受体）的体内功能：从发现到体内功能
4. Role of Estrogens and Their Receptors in Adhesion and Invasiveness of Breast Cancer Cells [C] . Marie Maynadier, Philippe Nirde, Jean-Marie Ramire International Symposium on Hormonal Carcinogenesis . 2008

机译：雌激素及其受体在乳腺癌细胞粘附性和侵袭性中的作用
5. Gene regulation by estrogen and tamoxifen in estrogen-receptor positive and estrogen-receptor negative human breast cancer cells: Characterization and quantification by real-time PCR. [D] . Yuan, Xia. 2004

机译：雌激素受体阳性和雌激素受体阴性人类乳腺癌细胞中雌激素和他莫昔芬的基因调控：实时PCR的表征和定量。
6. Regulation of ERRα Gene Expression by Estrogen Receptor Agonists and Antagonists in SKBR3 Breast Cancer Cells: Differential Molecular Mechanisms Mediated by G Protein-Coupled Receptor GPR30/GPER-1 [O] . Yin Li, Lutz Birnbaumer, Christina T. Teng -1

机译：雌激素受体激动剂和拮抗剂在SKBR3乳腺癌细胞中对ERRα基因表达的调节：G蛋白偶联受体GPR30 / GPER-1介导的差异分子机制。
7. Regulation of ERRα Gene Expression by Estrogen Receptor Agonists and Antagonists in SKBR3 Breast Cancer Cells: Differential Molecular Mechanisms Mediated by G Protein-Coupled Receptor GPR30/GPER-1 [O] . Li, Yin, Birnbaumer, Lutz, Teng, Christina T. 2010

机译：雌激素受体激动剂和拮抗剂在SKBR3乳腺癌细胞中对ERRα基因表达的调节：G蛋白偶联受体GPR30 / GPER-1介导的差异分子机制。

GPER-1/GPR30 a novel estrogen receptor sited in the cell membrane: therapeutic coupling to breast cancer

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