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Implications of Toll-like receptors in Ebola infection

机译：Toll样受体在埃博拉感染中的影响

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Introduction: The potential roles of toll-like receptors (TLRs) in immunopathogenesis of Ebola virus disease should be unraveled to provoke possible prophylactic or therapeutic implications of TLRs for EVD.Areas covered: The Ebola virus (EBOV) infection virtually paralyses all the main mechanisms responsible for induction of type I interferon (IFN-I) response. To summarize, EBOV infection interferes with: a) the TIR-domain-containing adapter-inducing interferon- (TRIF) pathway that is mediated by TLR3 and TLR4 signaling; b) the interferon regulatory factor 7 (IRF7) pathway that is stimulated by TLR7 and TLR9; c) the intracellular signaling that is induced by retinoic acid-inducible gene 1 (RIG-I)-like receptors (RLRs); and d) the autocrine/paracrine feedback loop that is mediated by the IFN-stimulated gene factor 3 (ISGF3) complex. Upon infection with EBOV infection, TLR4 plays a key role in production of proinflammatory mediators.Expert opinion: It is theoretically possible that use of TLRs 3, 4, 7, and 9 agonists would be beneficial to improve the IFN-I response, despite their systemic side effects. Also, antagonist of TLR4 can be utilized to prevent production of proinflammatory cytokines. Additionally, it is highly recommended to design future investigations aimed at determining if the utilization of IFN-I would be beneficial for prophylactic/therapeutic programs of Ebola.
机译：引言：揭示了Toll样受体（TLRS）在埃博拉病毒疾病免疫病变中的潜在作用，以促使TLRS对EVD.ARS的可能预防性或治疗意义：埃博拉病毒（EBOV）感染几乎瘫痪了所有主要机制负责诱导I型干扰素（IFN-I）的反应。总而言之，EBOV感染干扰：a）由TLR3和TLR4信号传导介导的含TIR-结构域的适配器诱导干扰素 - （TRIF）途径; b）由TLR7和TLR9刺激的干扰素调节因子7（IRF7）途径; c）由视黄酸诱导型基因1（RIG-I）的受体（RLRS）诱导的细胞内信号传导;和d）由IFN刺激的基因因子3（ISGF3）复合物介导的自分泌/旁静脉反馈环。在对EBOV感染感染后，TLR4在促炎媒体的生产中起着关键作用。Pertt意见：理论上可能使用TLR 3,4,7和9个激动剂，尽管他们有利于改善IFN-I的反应。系统副作用。此外，TLR4的拮抗剂可用于防止生产促炎细胞因子。此外，强烈建议设计未来的研究，旨在确定IFN-I的利用是否有利于埃博拉的预防/治疗程序。

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