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MUC16 as a novel target for cancer therapy

机译：Muc16作为癌症治疗的新靶点

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Introduction: MUC16 is overexpressed in multiple cancers and plays an important role in tumorigeni-city and acquired resistance to therapy. Area covered: In this review, we describe the role of MUC16 under normal physiological conditions and during tumorigenesis. First, we provide a summary of research on MUC16 from its discovery as CA125 to present anti-MUC16 therapy trials that are currently in the initial phases of clinical testing. Finally, we discuss the reasons for the limited effectiveness of these therapies and discuss the direction and focus of future research. Expert opinion: Apart from its protective role in normal physiology, MUC16 contributes to disease progression and metastasis in several malignancies. Due to its aberrant overexpression, it is a promising target for diagnosis and therapy. Cleavage and shedding of its extracellular domain is the major barrier for efficient targeting of MUC16-expressing cancers. Concerted efforts should be undertaken to target the noncleaved cell surface retained portion of MUC16. Such efforts should be accompanied by basic research to understand MUC16 cleavage and decipher the functioning of MUC16 cytoplasmic tail. While previous efforts to activate anti-MUC16 immune response using anti-CA125 idiotype antibodies have met with limited success, ideification of neo-antigenic epitopes in MUC16 that correlate with improved survival have raised raised hopes for developing MUC16-targeted immunotherapy.
机译：简介：MUC16在多种癌症中过表达，在肿瘤城市中发挥着重要作用，并获得了对治疗的抵抗力。面积涵盖：在本次综述中，我们描述了MUC16在正常生理条件下和肿瘤术期间的作用。首先，我们从其发现作为CA125的发现研究了对MUC16的研究综述，以呈现目前处于临床试验初始阶段的抗MUC16治疗试验。最后，我们讨论了这些疗法有限有效性的原因，并讨论了未来研究的方向和重点。专家意见：除了在正常生理学中的保护作用外，MUC16在几个恶性肿瘤中有助于疾病进展和转移。由于其异常过度表达，它是诊断和治疗的有希望的靶标。细胞外结构域的切割和脱落是有效靶向MUC16表达癌症的主要屏障。应协调努力，以靶向MUC16的非植垢细胞表面保留部分。这种努力应伴随着理解Muc16切割和破译Muc16细胞质尾部的功能的基本研究。虽然以前使用抗CA125独立型抗体激活抗MUC16免疫应答的努力，但成功有限，但MUC16中新抗原表位的识别与改善的存活相关，提高了升高的希望开发MUC16靶向免疫疗法。

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