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Chaperone-mediated autophagy as a therapeutic target for Parkinson disease

机译：伴侣介导的自噬作为帕金森病的治疗靶标

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Introduction: Parkinson disease (PD) is the most common neurodegenerative movement disorder. Currently only symptomatic treatments exist for PD, and so the search for potential neuroprotective drug targets is of great importance. Chaperone mediated autophagy (CMA) is one of the key cellular mechanisms in protein homeostasis. Many of the pathogenic pathways thought to be important in PD converge on CMA, thus rendering it an attractive therapeutic target. Areas covered: In this review we discuss current up-to-date knowledge of the molecular mechanisms involved in CMA function and regulation. We go on to discuss the links between CMA and PD including CMA's role in a-synuclein processing, oxidative stress, and mitochondrial function. We finish by exploring the potential benefits of how upregulation of CMA may be beneficial in PD and strategies to achieve this. Expert opinion: Upregulation of CMA is an attractive therapeutic target in PD due to its links with several pathogenic pathways . Currently more knowledge of the mechanisms that regulate CMA is required to allow for the development of specific CMA modulators. However, recent studies demonstrating the role of retinoic acid derivatives and miRNAs in regulating CMA are promising, and indirect upregulation of CMA by modulating other lysosomal pathways may be helpful.
机译：简介：帕金森病（PD）是最常见的神经退行性运动障碍。目前只有对症状治疗存在于PD，因此寻求潜在的神经保护药物目标是非常重要的。伴侣介导的自噬（CMA）是蛋白质稳态中的关键细胞机制之一。许多致病途径认为在CMA上的PD中很重要，从而使其成为一种有吸引力的治疗目标。所涵盖的区域：在本报告中，我们讨论了CMA功能和监管中涉及的分子机制的最新知识。我们继续讨论CMA和PD之间的链接，包括CMA在X型突出蛋白加工，氧化应激和线粒体功能中的作用。我们通过探索CMA的上调如何有益的潜在好处，以实现这一目标的策略。专家意见：由于其具有几种致病途径的环节，CMA的上调是PD中的有吸引力的治疗目标。目前，需要了解调节CMA的机制，以允许开发特定的CMA调制器。然而，最近的研究证明了视黄酸衍生物和miRNA在调节CMA中的作用是有前途的，并且通过调节其他溶酶体途径的间接上调CMA可能有所帮助。

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