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Targeted therapy to annihilate the immune-evading phenotype in cancer evolution

机译:有针对性的疗法将免疫疏忽癌症进化中的免疫表型灭绝

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摘要

Cancer is a moving target, and targeted therapy must ultimately deal with the evolution of the disease. This is because evolution is the substrate for development of resistance to targeted therapy [1]. A successful therapeutic strategy is one that can tackle and ultimately eliminate the evading phenotype. Thus, to steer cancer evolution for therapeutic purposes, one must first note that targeted therapy imposes selection pressure and resistant phenotypes prevail in a context of clonal heterogeneity. The quest for complete cure makes it imperative to control the evolutionary fate of the tumor.
机译:癌症是一个移动的目标,有针对性的治疗必须最终应对疾病的演变。 这是因为进化是用于发展靶向治疗的抗性的基材[1]。 成功的治疗策略是可以解决和最终消除逃避表型的策略。 因此,为了引导癌症演变以进行治疗目的,必须首先注意靶向治疗施加的选择压力和抗性表型在克隆异质性的背景下占上风。 追求完全治愈使其必须控制肿瘤的进化命运。

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