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首页> 外文期刊>Expert opinion on therapeutic targets >Signaling pathways as therapeutic targets in biliary tract cancer
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Signaling pathways as therapeutic targets in biliary tract cancer

机译：作为胆道癌症的治疗靶标的信号传导途径

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Introduction: The incidence of biliary tract cancer (BTC) is increasing, and the disease is frequently diagnosed during advanced stages, leading to poor overall survival. Limited treatment options are currently available and novel therapeutic approaches are needed. A number of completed clinical trials have evaluated the role of chemotherapy for BTC, demonstrating a marginal benefit. Thus, there is increased interest in applying targeted therapies for this disease.Areas covered: This review article summarizes the role of chemotherapeutic regimens for the treatment of BTC, and highlights key signal transduction pathways of interest for targeted inhibition. Of particular interest are the MEK or MAP2K (mitogen-activated protein kinase kinase), phosphatidylinositol-3 kinase (PI3K) and signal transducer and activator of transcription-3 (STAT3) pathways. We discuss the available data on several promising inhibitors of these pathways, both in the pre-clinical and clinical settings.Expert opinion: Future treatment strategies should address targeting of MEK, PI3K and STAT3 for BTC, with a focus on combined therapeutic approaches.
机译：介绍：胆道癌症（BTC）的发病率越来越多，疾病经常在高级阶段诊断，导致总体存活差。目前可获得有限的治疗方案，需要进行新的治疗方法。许多完成的临床试验评估了BTC化疗的作用，展示了边际益处。因此，对这种疾病的靶向治疗有兴趣增加。覆盖：本综述文章总结了化学治疗方案对BTC治疗的作用，并突出了有针对性抑制的关键信号转导途径。特别感兴趣的是MEK或MAP2K（丝分裂剂激活蛋白激酶激酶），磷脂酰肌醇-3激酶（PI3K）和转录-3（STAT3）途径的信号传感器和活化剂。我们在临床前和临床环境中讨论这些途径的几种有前途抑制剂的可用数据.Pert意见：未来的治疗策略应该解决MEK，PI3K和Stat3的针对BTC的目标，重点是组合治疗方法。

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