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Novel therapeutic strategy targeting the Hedgehog signalling and mTOR pathways in biliary tract cancer

机译：针对胆道癌中Hedgehog信号通路和mTOR通路的新型治疗策略

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摘要

Background: Activation of the PI3K/mTOR and Hedgehog (Hh) signalling pathways occurs frequently in biliary tract cancer (BTC). Crosstalk between these pathways occurs in other gastrointestinal cancers. The respective signalling inhibitors rapamycin and vismodegib may inhibit BTC synergistically and suppress cancer stem cells (CSCs).

机译：背景：PI3K / mTOR和刺猬（Hh）信号通路的激活在胆管癌（BTC）中经常发生。这些途径之间的串扰发生在其他胃肠道癌症中。各自的信号抑制剂雷帕霉素和vismodegib可以协同抑制BTC并抑制癌症干细胞（CSC）。

著录项

期刊名称 British Journal of Cancer
作者
M Zuo; A Rashid; C Churi; J-N Vauthey; P Chang; Y Li; M-C Hung; D Li; M Javle;
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作者单位

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年(卷),期 2015(112),6
年度 2015
页码 1042–1051
总页数 10
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
BTC mTOR inhibitor Hedgehog inhibitor combination therapy;

机译：BTC;mTOR抑制剂;刺猬抑制剂;联合疗法;

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专利

1. Novel therapeutic strategy targeting the Hedgehog signalling and mTOR pathways in biliary tract cancer [J] . M Zuo, A Rashid, C Churi, British Journal of Cancer . 2015,第6期

机译：针对胆道癌中刺猬信号和mTOR通路的新型治疗策略
2. PI3K-mTOR pathway identified as a potential therapeutic target in biliary tract cancer using a newly established patient-derived cell panel assay [J] . Sakamoto Yasunari, Yamagishi Seri, Tanizawa Yoshinori, Japanese journal of clinical oncology. . 2018,第4期

机译：使用新建立的患者衍生的细胞面板测定鉴定为胆囊癌的潜在治疗靶标的PI3K-MTOR途径
3. Signaling pathways as therapeutic targets in biliary tract cancer [J] . Yang Jennifer, Farren Matthew R., Ahn Daniel, Expert opinion on therapeutic targets . 2017,第1a6期

机译：作为胆道癌症的治疗靶标的信号传导途径
4. Proteomic strategies for the identification of potential drug targets within the T cell mTOR-Raptor mediated signal transduction pathway [C] . Christine A. Jelinek, Thomas P. Kole, Greg M. Delgoffe, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：蛋白质组学策略鉴定T细胞MTOR-RAPTOR介导的信号转导途径中的潜在药物靶标
5. Combination therapeutic strategies targeting growth and metabolic pathways in prostate cancer. [D] . Canatsey, Ryan Douglas. 2016

机译：针对前列腺癌的生长和代谢途径的联合治疗策略。
6. Signaling Pathways as Therapeutic Targets in Biliary Tract Cancer [O] . Jennifer Yang, Matthew R. Farren, Daniel Ahn, -1

机译：信号通路作为胆道癌的治疗靶点
7. PI3K-mTOR pathway identified as a potential therapeutic target in biliary tract cancer using a newly established patient-derived cell panel assay [O] . Yasunari Sakamoto, Seri Yamagishi, Yoshinori Tanizawa, 2018

机译：使用新建立的患者衍生的细胞面板测定，鉴定为胆道癌中的潜在治疗靶标的PI3K-MTOR途径
8. Targeting Tissue Factor-Factor VIIa Signaling Pathway to Enhance Activity of mTOR Inhibitors in the Treatment of Breast Cancer [R] . Bromberg, M. 2010

机译：靶向组织因子 - 因子VIIa信号通路以增强mTOR抑制剂在乳腺癌治疗中的活性

Novel therapeutic strategy targeting the Hedgehog signalling and mTOR pathways in biliary tract cancer

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