Recent advances in targeting protein arginine methyltransferase enzymes in cancer therapy

Smith Emily; Zhou Wei; Shindiapina Polina; Sif Said; Li Chenglong; Baiocchi Robert A.

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Recent advances in targeting protein arginine methyltransferase enzymes in cancer therapy

机译：靶向蛋白质精氨酸甲基转移酶在癌症治疗中的最新进展

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Introduction: Exploration in the field of epigenetics has revealed the diverse roles of the protein arginine methyltransferase (PRMT) family of proteins in multiple disease states. These findings have led to the development of specific inhibitors and discovery of several new classes of drugs with potential to treat both benign and malignant conditions.

机译：简介：外膜遗传学领域的探讨揭示了蛋白质精氨酸甲基转移酶（PRMT）蛋白质在多种疾病状态中的不同作用。这些发现导致特定抑制剂的发展和发现几种新的药物，潜力可以治疗良性和恶性条件。

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来源
《Expert opinion on therapeutic targets》 |2018年第6期|共19页
作者
Smith Emily; Zhou Wei; Shindiapina Polina; Sif Said; Li Chenglong; Baiocchi Robert A.;
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作者单位

Ohio State Univ Dept Internal Med Div Hematol Columbus OH 43210 USA;

Univ Florida Coll Med Dept Biochem &

Mol Biol Gainesville FL 32610 USA;

Ohio State Univ Dept Internal Med Div Hematol Columbus OH 43210 USA;

Qatar Univ Coll Arts &

Sci Dept Biol &

Environm Sci Doha Qatar;

Univ Florida Coll Med Dept Biochem &

Mol Biol Gainesville FL 32610 USA;

Ohio State Univ Dept Internal Med Div Hematol Columbus OH 43210 USA;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Cancer; arginine-methylation; epigenetics; therapeutic target;

机译：癌症;精氨酸 - 甲基化;表观遗传学;治疗目标;

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专利

1. Recent advances in targeting protein arginine methyltransferase enzymes in cancer therapy [J] . Smith Emily, Zhou Wei, Shindiapina Polina, Expert opinion on therapeutic targets . 2018,第1a6期

机译：靶向蛋白质精氨酸甲基转移酶在癌症治疗中的最新进展
2. Protein arginine methyltransferase 5: A novel therapeutic target for triple‐negative breast cancers [J] . Mathilde Vinet, Samyuktha Suresh, Virginie Maire, Cancer Medicine . 2019,第5期

机译：蛋白质精氨酸甲基转移酶5：三阴性乳腺癌的新型治疗靶点
3. Protein arginine methyltransferase 5: a potential cancer therapeutic target [J] . Yuan Yuanyang, Nie Hong Cellular oncology . 2021,第1期

机译：蛋白质精氨酸甲基转移酶5：潜在的癌症治疗靶标
4. Reactive Oxygen Species (ROS)-responsive Protein Modification and Its Intracellular Delivery for Targeted Cancer Therapy [C] . Qiaobing Xu, Ming Wang Society for Biomaterials annual meeting and exposition . 2015

机译：活性氧（ROS）响应蛋白修饰及其在靶向癌症治疗中的细胞内递送
5. Kinetic Analysis of Small Molecule Inhibitors Targeting Protein Arginine Methyltransferase-5 (PRMT5) Using Surface Plasmon Resonance (Spr) [D] . Baker, Lynn Kim. 2020

机译：用表面等离子体共振（SPR）靶向蛋白质精氨酸甲基转移酶-5（PRMT5）的小分子抑制剂的动力学分析
6. Recent advances in targeting protein arginine methyltransferase enzymes in cancer therapy [O] . Emily Smith, Wei Zhou, Polina Shindiapina, -1

机译：靶向蛋白精氨酸甲基转移酶在癌症治疗中的最新进展
7. Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers [O] . Lakshmi Prabhu, Han Wei, Lan Chen, 2017

机译：适应Alphalisa高通量筛网以发现靶向蛋白质精氨酸甲基转移酶5的新型小分子抑制剂在胰腺和结肠直肠癌中

Recent advances in targeting protein arginine methyltransferase enzymes in cancer therapy

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