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Targeting SOX2 in anticancer therapy

机译：靶向SOX2在抗癌治疗中

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Introduction: SOX2 is a transcription factor that is important in the development and maintenance of the stem cell state. Furthermore, SOX2 is associated with cancer progression because it promotes the migration, invasion, and proliferation of cancer cells. SOX2 is also expressed in cancer stem cells and appears to be involved in the resistance toward anticancer therapies. These features render SOX2 an attractive target for cancer therapy. Areas covered: In this review, we highlight the role of SOX2 in cancer and in the resistance toward anticancer therapies. We summarize recent studies dealing with SOX2 as a direct or indirect therapeutic target in cancer. Expert opinion: SOX2 is an attractive target in cancer therapy because of its role in cancer progression and therapy resistance. SOX2 is a transcription factor, hence direct targeting is difficult. Studies aimed at a functional depletion, for example by knock-down with siRNAs, are difficult to translate into clinical settings. Alternatively, the identification of SOX2 upstream or downstream regulators that are easier to target is of paramount importance.
机译：简介：SOX2是一种转录因子，在干细胞状态的开发和维持方面是重要的。此外，SOX2与癌症进展有关，因为它促进了癌细胞的迁移，侵袭和增殖。 SOX2也以癌症干细胞表达，似乎参与抗抗癌疗法的抵抗力。这些特征使SOX2具有癌症治疗的有吸引力的目标。所涵盖的地区：在本综述中，我们突出了SOX2在癌症中的作用和对抗癌疗法的抵抗力。我们总结了最近将SOX2处理的研究作为癌症中的直接或间接治疗靶标。专家意见：SOX2是癌症治疗中有吸引力的靶标，因为它在癌症进展和治疗抵抗中的作用。 SOx2是转录因子，因此直接靶向是困难的。针对功能耗尽的研究，例如通过与siRNA的敲低，难以转化为临床环境。或者，识别更容易靶向的SOx2上游或下游调节器是至关重要的。

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