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Flow-Synchronized Nasal Intermittent Positive Pressure Ventilation for Infants 32 Weeks Gestation with Respiratory Distress Syndrome

机译:小于32周妊娠合并呼吸窘迫综合征的婴儿的气流同步鼻间歇正压通气。

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摘要

Aim. To evaluate whether synchronized-NIPPV (SNIPPV) used after the INSURE procedure can reduce mechanical ventilation (MV) need in preterm infants with RDS more effectively than NCPAP and to compare the clinical course and the incidence of short-term outcomes of infants managed with SNIPPV or NCPAP. Methods. Chart data of inborn infants <32 weeks undergoing INSURE approach in the period January 2009–December 2010 were reviewed. After INSURE, newborns born January –December 2009 received NCPAP, whereas those born January–December 2010 received SNIPPV. INSURE failure was defined as FiO2 need >0.4, respiratory acidosis, or intractable apnoea that occurred within 72 hours of surfactant administration. Results. Eleven out of 31 (35.5%) infants in the NCPAP group and 2 out of 33 (6.1%) infants in the SNIPPV group failed the INSURE approach and underwent MV (P < 0.004). Fewer infants in the INSURE/SNIPPV group needed a second dose of surfactant, a high caffeine maintenance dose, and pharmacological treatment for PDA. Differences in O2 dependency at 28 days and 36 weeks of postmenstrual age were at the limit of significance in favor of SNIPPV treated infants. Conclusions. SNIPPV use after INSURE technique in our NICU reduced MV need and favorably affected short-term morbidities of our premature infants.
机译:目标。评估在INSURE程序后使用同步NIPPV(SNIPPV)是否能比NCPAP更有效地减少RDS早产儿的机械通气(MV)需求,并比较SNIPPV所治疗婴儿的临床病程和短期结局发生率或NCPAP。方法。回顾了2009年1月至2010年12月期间采用INSURE方法的32周以下的出生婴儿的图表数据。 INSURE之后,2009年1月至12月出生的新生儿接受了NCPAP,而2010年1月至12月出生的新生儿接受了SNIPPV。 INSURE失败的定义为FiO2需求> 0.4,呼吸性酸中毒或表面活性剂给药72小时内发生的难治性呼吸暂停。结果。 NCPAP组的31名婴儿中有11名(35.5%)和SNI​​PPV组的33名婴儿中有2名(6.1%)未通过INSURE方法并接受了MV(P <0.004)。 INSURE / SNIPPV组的婴儿较少,需要第二剂表面活性剂,高咖啡因维持剂量和PDA的药物治疗。月经后28天和36周时O2依赖性的差异在显着性限度内有利于SNIPPV治疗的婴儿。结论。在我们的重症监护病房中使用INSURE技术后的SNIPPV减少了MV需求,并有利地影响了我们早产儿的短期发病率。

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