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首页> 美国卫生研究院文献>Comparative Medicine >Protective Effect of Inositol Hexaphosphate Against UVB Damage in HaCaT Cells and Skin Carcinogenesis in SKH1 Hairless Mice
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Protective Effect of Inositol Hexaphosphate Against UVB Damage in HaCaT Cells and Skin Carcinogenesis in SKH1 Hairless Mice

机译：六磷酸肌醇对SKH1无毛小鼠HaCaT细胞UVB损伤和皮肤致癌作用的保护作用

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摘要

UVB radiation damages keratinocytes, potentially inducing chronic skin damage, cutaneous malignancy, and suppression of the immune system. Naturally occurring agents have been considered for prevention and treatment of various kinds of cancer, including skin cancer. Inositol hexaphosphate (IP6), an antioxidant, is a naturally occurring polyphosphorylated carbohydrate that has shown a strong anticancer activity in several experimental models. We assessed the protective effects of IP6 against UVB irradiation-induced injury and photocarcinogenesis by using HaCaT cells (human immortalized keratinocytes) and SKH1 hairless mice. We found that IP6 counteracts the harmful effects of UVB irradiation and increases the viability and survival of UVB-exposed cells. Treatment with IP6 after UVB irradiation (30 mJ/cm2) arrested cells in the G1 and G2M phases while decreasing the S phase of the cell cycle. Treatment with IP6 also decreased UVB-induced apoptosis and caspase 3 activation. Topical application of IP6 followed by exposure to UVB irradiation in SKH1 hairless mice decreased tumor incidence and multiplicity as compared with control mice. Our results suggest that IP6 protects HaCaT cells from UVB-induced apoptosis and mice from UVB-induced tumors.
机译：UVB辐射会损害角质形成细胞，从而潜在地引起慢性皮肤损害，皮肤恶性肿瘤和免疫系统抑制。已经考虑将天然存在的试剂用于预防和治疗各种癌症，包括皮肤癌。六磷酸肌醇（IP6）是一种抗氧化剂，是一种天然存在的多磷酸化碳水化合物，在多种实验模型中均显示出强大的抗癌活性。我们通过使用HaCaT细胞（人类永生化角质形成细胞）和SKH1无毛小鼠评估了IP6对UVB辐射诱导的损伤和光致癌作用的保护作用。我们发现IP6抵消了UVB辐射的有害影响，并增加了暴露于UVB的细胞的活力和存活率。 UVB照射（30 mJ / cm 2 ）后用IP6处理使细胞处于G1和G2M期，同时降低了细胞周期的S期。 IP6处理还减少了UVB诱导的细胞凋亡和caspase 3活化。与对照小鼠相比，在SKH1无毛小鼠中局部施用IP6，然后暴露于UVB辐射可降低肿瘤发生率和多样性。我们的结果表明IP6保护HaCaT细胞免受UVB诱导的细胞凋亡，保护小鼠免受UVB诱导的肿瘤。

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