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首页> 外文期刊>Comparative Medicine >Effect of inositol hexaphosphate on the development of uvb-induced skin tumors in SKH1 hairless mice
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Effect of inositol hexaphosphate on the development of uvb-induced skin tumors in SKH1 hairless mice

机译：六磷酸肌醇对SKH1无毛小鼠uvb诱导的皮肤肿瘤发展的影响

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摘要

Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate that is abundant in many plants and in various high-fiber foods, such as cereals and legumes. IP6 has a striking, broad-spectrum anticancer activity in various in vitro and animal models, in which it interferes with key pathways in malignancy to inhibit cell proliferation, cell-cycle progression, metastasis, invasion, and angiogenesis and to induce apoptosis. In this study, we investigated the protective effects of IP6 in drinking water on the incidence of UVB-induced skin cancer in the SKH1 (Crl: SKH1-hr) mouse model. One group of 15 mice received 2% IP6 in drinking water and UVB exposure, and the other group (n = 15) received UVB exposure only. All mice in both groups were fed an IP6-deficient diet (AIN 76A). The treatment group started receiving 2% IP6 in the drinking water 3 d before irradiation. Mice were irradiated 3 times each week, starting at a dose of 1.5 kJ/m2, with weekly increases in increments of 1.5 kJ/m2 to a final dose of 7.5 kJ/m2. Tumor formation was monitored until the week 31. IP6 in drinking water significantly decreased tumor incidence by 5-fold and tumor multiplicity by 4-fold. These results show that IP6 has an antiphotocarcinogenic effect and can protect against UVB-induced tumor formation.
机译：六磷酸肌醇（IP6）是一种天然存在的多磷酸化碳水化合物，在许多植物和各种高纤维食品（例如谷物和豆类）中含量丰富。 IP6在各种体外和动物模型中均具有惊人的广谱抗癌活性，其中IP6会干扰恶性肿瘤的关键途径，从而抑制细胞增殖，细胞周期进程，转移，侵袭和血管生成，并诱导细胞凋亡。在这项研究中，我们研究了饮用水中IP6对SKH1（Crl：SKH1-hr）小鼠模型中UVB诱导的皮肤癌发生率的保护作用。一组15只小鼠的饮用水和UVB暴露量为2％IP6，另一组（n = 15）仅接受UVB暴露。两组中的所有小鼠均饲喂IP6缺乏饮食（AIN 76A）。治疗组在照射前3天开始在饮用水中接受2％IP6。从剂量为1.5 kJ / m2开始，每周照射小鼠3次，每周增加一次，剂量为1.5 kJ / m2，最终剂量为7.5 kJ / m2。监测肿瘤形成直至第31周。饮用水中的IP6可使肿瘤发生率显着降低5倍，而肿瘤多样性则降低4倍。这些结果表明，IP6具有抗光致癌作用，可以防止UVB诱导的肿瘤形成。

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