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首页> 美国卫生研究院文献>The Journal of Veterinary Medical Science >Recovery of Bordetella bronchiseptica sequence type 82 and B. pseudohinzii from urban rats in Terengganu Malaysia
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Recovery of Bordetella bronchiseptica sequence type 82 and B. pseudohinzii from urban rats in Terengganu Malaysia

机译：从马来西亚登嘉楼市的城市鼠中回收支气管败血波氏杆菌82型和伪隐孢子虫

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Rodents have historically been associated with zoonotic pandemics that claimed the lives of large human populations. Appropriate pathogen surveillance initiatives could contribute to early detection of zoonotic infections to prevent future outbreaks. Bordetella species are bacteria known to cause mild to severe respiratory disease in mammals and, some have been described to infect, colonize and spread in rodents. There is a lack of information on the population diversity of bordetellae among Malaysian wild rodents. Here, bordetellae recovered from lung tissues of wild rats were genotypically characterized using 16S rDNA sequencing, MLST and nrdA typing. A novel B. bronchiseptica ST82, closely related to other human-derived isolates, was discovered in three wild rats (n=3) from Terengganu (5.3333° N, 103.1500° E). B. pseudohinzii, a recently identified laboratory mice inhabitant, was also recovered from one rat (n=1). Both bordetellae displayed identical antimicrobial resistance profiles, indicating the close phylogenetic association between them. Genotyping using the 765-bp nrdA locus was shown to be compatible with the MLST-based phylogeny, with the added advantage of being able to genotype non-classical bordetellae. The recovery of B. pseudohinzii from wild rat implied that this bordetellae has a wider host range than previously thought. The findings from this study suggest that bordetellae surveillance among wild rats in Malaysia has to be continued and expanded to other states to ensure early identification of species capable of causing public health disorder.
机译：啮齿动物历来与人畜共患大流行有关，人畜共患大流行夺走了大批人口的生命。适当的病原体监测措施可能有助于及早发现人畜共患病感染，以防止未来爆发。博德特氏菌是已知在哺乳动物中引起轻度至重度呼吸道疾病的细菌，并且已经描述了其中的一些可在啮齿动物中感染，定殖和传播。缺乏有关马来西亚野生啮齿类动物波尔氏菌种群多样性的信息。在这里，使用16S rDNA测序，MLST和nrdA分型对从野生大鼠肺组织中回收的紫菜进行基因型分析。在来自登嘉楼（5.3333°N，103.1500°E）的三只野生大鼠（n = 3）中发现了一种与其他人源分离株密切相关的新型支气管败血杆菌。还从一只大鼠中回收了最近鉴定为实验小鼠的B. pseudohinziii（n = 1）。两种紫菜都显示出相同的抗药性，表明它们之间的亲缘关系很密切。研究表明，使用765 bp nrdA基因座进行基因分型与基于MLST的系统发育兼容，并具有能够对非经​​典bordetellae进行基因分型的额外优势。从野生大鼠中回收假乙型芽孢杆菌意味着该波尔德氏菌宿主范围比以前认为的要广。这项研究的结果表明，必须继续在马来西亚野鼠中监视波尔氏菌，并将其扩展到其他州，以确保及早发现能够引起公共卫生疾病的物种。

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