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首页> 外文会议>Congress of the International Pig Veterinary Society >COMPARATIVE SEQUENCE ANALYSIS OF BORDETELLA BRONCHISEPTICA PERTACTIN GENE REPEAT REGIONS
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COMPARATIVE SEQUENCE ANALYSIS OF BORDETELLA BRONCHISEPTICA PERTACTIN GENE REPEAT REGIONS

机译：Bordetella Bronchiseptica pertactin基因重复区域的比较序列分析

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摘要

Bordetella bronchiseptica is an etiologic agent of atrophic rhinitis and primary bronchopneumonia in young pigs. It may also increase the frequency and severity of respiratory disease due to PRRSV and other pathogens (1,2). The product of the B. bronchiseptica pertactin gene, pm, has been implicated as an adhesin and a protective immunogen in swine. Recent studies demonstrate prn sequence heterogeneity in swine isolates and vaccine strains within and surrounding the region 1 amino acid repeat GGXXP_nand the region 2 amino acid repeat PQP_n (3,4). However, only a few isolates were evaluated. Allelic variation between vaccine strains and field isolates may affect vaccine efficacy, since region 2 is known to encode an immunodominant protective epitope(5). The present study describes the results of comparative sequence analysis of prn regions 1 and 2 from 30 recent swine field isolates and 3 vaccine strains.
机译：Bordetella Bronchiseptica是萎缩性鼻炎和幼猪的原发性支气管炎的病因试剂。由于PRRSV和其他病原体（1,2），它也可能增加呼吸系统疾病的频率和严重程度。 B.Bronchiseptica pertactin基因，PM的产物涉及乳剂和猪中的保护性免疫原。最近的研究证明了猪分离物中的PRN序列异质性，并且在区域1氨基酸内和周围的疫苗菌株重复GGXXP_NAND，该区域2氨基酸重复PQP_N（3,4）。但是，只评估几个分离物。疫苗菌株和野外分离物之间的等位基因变异可能影响疫苗功效，因为已知区域2编码免疫模数保护表位（5）。本研究描述了PRN区1和2的比较序列分析结果，从最近的30个猪场分离物和3个疫苗菌株。

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