首页> 外国专利> Polypeptides containing polymorphisms of the repeat regions of pertactin from bordetella pertussis, bordetella parapertussis and bordetella bronchiseptica, their use in diagnostics and in immunogenic preparations

Polypeptides containing polymorphisms of the repeat regions of pertactin from bordetella pertussis, bordetella parapertussis and bordetella bronchiseptica, their use in diagnostics and in immunogenic preparations

机译：含有百日咳博德特氏菌，副百日咳博德特氏菌和支气管败血性博德特氏菌百日咳杆菌粘附素重复区多态性的多肽，其在诊断和免疫原性制剂中的用途

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摘要

Pertactin (PRN) is an outer membrane protein expressed by Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica, which induces protective immunity to Bordetella infections. The immunodominant and immunoprotective epitopes of pertactin include two repeated regions, I and II. Comparison of these two repeated regions showed the pertactin of B. parapertussis is invariant, whereas the pertactin of B. pertussis varies mostly in region I and B. bronchiseptica varies in both the repeated regions I and II. Compositions containing pertactins and pertactin

机译：百日咳杆菌粘附素（PRN）是百日咳博德特氏菌，副百日咳博德特氏菌和支气管博德特氏菌表达的一种外膜蛋白，可诱导针对博德特氏菌感染的保护性免疫。 pertactin的免疫优势和免疫保护性表位包括两个重复区域I和II。这两个重复区域的比较显示，副百日咳博德特氏菌的百日咳杆菌粘附素是不变的，而百日咳博德特氏菌的百日咳杆菌粘附素在区域I和B中主要变化。含有百日咳杆菌粘附素和百日咳杆菌粘附素的组合物

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公开/公告号DK1284993T3

专利类型
公开/公告日2008-07-28

原文格式PDF
申请/专利权人 INSTITUT PASTEUR;
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申请/专利号DK20010945261T
发明设计人 GUISO-MACLOUF NICOLE;BOURSAUX-EUDE CAROLINE;
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申请日2001-05-23
分类号C07K14/235;G01N33/53;A61K39;A61K39/10;A61K39/395;A61K39/40;A61K48;A61P31/04;C07K16/12;C07K19;C12M1;C12N15/09;C12N15/31;C12P21/08;C12Q1/68;C12Q1/689;C12R1/01;G01N27/447;G01N33/566;G01N33/569;
国家 DK
入库时间 2022-08-21 20:08:24

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