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首页> 美国卫生研究院文献>The Journal of Veterinary Medical Science >Visual evoked potential in rabbits’ eyes with subretinal implantation byvitrectomy of Okayama University-type retinal prosthesis(OURePTM)
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Visual evoked potential in rabbits’ eyes with subretinal implantation byvitrectomy of Okayama University-type retinal prosthesis(OURePTM)

机译：视网膜下植入兔眼的视觉诱发电位冈山大学型视网膜假体玻璃体切除术（OURePTM）

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Okayama University-type retinal prosthesis (OURePTM) is a photoelectric dye-coupled polyethylene film which generates electric potential in response to light and stimulates nearby neurons. This study aims to test surgical feasibility for subretinal film implantation and to examine functional durability of films in subretinal space. Dye-coupled films were implanted subretinally by vitrectomy in the right eye of normal white rabbits: 8 rabbits for 1 month and 8 rabbits for 6 months. The implanted films were removed by vitrectomy in 4 of these 8 rabbits in 1-month or 6-month implantation group. The films were also implanted in 4 rhodopsin-transgenic retinal dystrophic rabbits. Visual evoked potential was measured before film implantation as well as 1 or 6 months after film implantation, or 1 month after film removal. The films were successfully implanted in subretinal space of retinal detachment induced by subretinal fluid injection with a 38G polyimide tip. The retina was reattached by fluid-air exchange in vitreous cavity, retinal laser coagulation, and silicone oil injection. The ratios of P2 amplitudes of visual evoked potential in the implanted right eye over control left eye did not show significant changes between pre-implantation and post-implantation or post-removal (paired t-test). In Kelvin probe measurements, 4 pieces each of removed films which were implanted for 1 or 6 months showed proportional increase of surface electricpotential in response to increasing light intensity. The film implantation was safe andimplanted films were capable of responding to light.
机译：冈山大学型视网膜假体（OUReP TM ）是一种光电耦合的聚乙烯薄膜，可对光产生电势并刺激附近的神经元。这项研究旨在测试视网膜下膜植入的手术可行性，并检查视网膜下空间膜的功能耐久性。通过玻璃体切除术在正常白兔的右眼视网膜下植入染料偶联膜：8只兔子1个月，8只兔子6个月。在1个月或6个月植入组中，这8只兔子中有4只通过玻璃体切除术去除了植入的膜。还将这些膜植入4只视紫红质转基因视网膜营养不良的兔子中。在膜植入前以及膜植入后1或6个月，或膜去除后1个月，测量视觉诱发电位。将膜成功植入38G聚酰亚胺针头注入视网膜下液诱导的视网膜脱离的视网膜下间隙中。视网膜通过玻璃体腔中的流体-空气交换，视网膜激光凝结和硅油注射而重新附着。植入前右眼与对照左眼之间的视觉诱发电位的P2振幅比在植入前与植入后或切除后（配对t检验）之间未显示出显着变化。在开尔文（Kelvin）探针测量中，分别植入4片被去除的薄膜，植入1或6个月后，表面电势成比例增加响应增加的光强度。膜植入是安全的，并且植入的膜能够对光作出反应。

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