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首页> 美国卫生研究院文献>The Journal of Venomous Animals and Toxins Including Tropical Diseases >Exposure to 50 Hz electromagnetic field changes the efficiency of the scorpion alpha toxin
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Exposure to 50 Hz electromagnetic field changes the efficiency of the scorpion alpha toxin

机译：暴露于50 Hz电磁场会改变蝎子α毒素的效率

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BackgroundExtremely low-frequency (50 Hz) electromagnetic field (ELF-EMF) is produced by electric power transmission lines and electronic devices of everyday use. Some phenomena are proposed as “first effects” of ELF-EMF: the discrete changes in the membrane potential and the increase of the calcium channel activity as well as the intracellular concentration of Ca2+. Interaction of the scorpion alpha toxin with the sodium channel depends on the orientation of the charges and may be perturbed by changes in the membrane polarization. The toxin induces overexcitability in the nervous system and an increase in the neurotransmitters released with different consequences, mainly the paralysis of muscles. We assumed that the exposure to ELF-EMF 0.7 mT will change the effects of the insect selective scorpion alpha toxin (recombinant LqhαIT from Leiurus quinquestriatus hebraeus) at the level of the cercal nerve function, the synaptic transmission and on the level of entire insect organism. Taking into account the compensatory mechanisms in organisms, we tested in addition ten times higher ELF-EMF on whole insects.
机译：背景技术输电线路和日常使用的电子设备会产生极低频（50 Hz）的电磁场（ELF-EMF）。某些现象被认为是ELF-EMF的“第一效应”：膜电位的离散变化和钙通道活性的增加以及细胞内Ca 2 + 的浓度。蝎子α毒素与钠通道的相互作用取决于电荷的方向，并可能受到膜极化变化的干扰。毒素在神经系统中引起过度兴奋，释放的神经递质增加，其后果不同，主要是肌肉麻痹。我们假设暴露于0.7 mT的ELF-EMF会在大脑神经功能水平，突触传递以及整个昆虫生物体水平上改变昆虫选择性蝎α毒素（来自Leiurus quinquestriatus hebraeus的重组LqhαIT）的影响。考虑到生物体内的补偿机制，我们对整个昆虫进行了10倍高的ELF-EMF测试。

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