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Three Scientific Controversies to Engage Students in Reading Primary Literature

机译:吸引学生阅读小学文学作品的三项科学争议

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摘要

In this review, three sets of papers are presented. Each of the sets presents a historical or active controversy in neuroscience ranging from cell biology and cell signaling, to developmental neuroscience, to cognitive neuroscience. The first set captures a historical controversy about whether the beta/gamma subunit of G-proteins can be active in opening ion channels. The second set represents a modern instantiation of the oldest debate in neuroscience: are our minds and brains the product of innate factors or environmental influences. This debate plays out in a series of papers on the development of the visual system. The third set contrasts the view that the hippocampus and surrounding structures primarily function to represent our location in space (a position for which the 2014 Nobel Prize in Physiology or Medicine was awarded to three investigators) with the perspective that the hippocampus is a general-purpose structure for declarative memories, spatial or non-spatial. The first and third controversies feature publications of virtually identical experiments that show opposing results. All three controversies are discussed in regards to the individual scientists who did the experiments and debated directly with each other. The first (beta/gamma subunits) emphasizes the value of reproducibility in scientific research, the second (visual cortex development) emphasizes the value of new techniques and updating scientific models, and the third (hippocampus) exposes students to an ongoing, albeit under discussed, debate.
机译:在这篇评论中,提出了三套论文。每组都提出了神经科学方面的历史或活跃争议,涉及范围从细胞生物学和细胞信号传导到发育神经科学到认知神经科学。第一组记录了有关G蛋白的β/γ亚基是否可以在开放离子通道中起作用的历史争议。第二组代表了神经科学中最古老的争论的现代实例:我们的思想和大脑是先天因素或环境影响的产物。这场辩论在有关视觉系统发展的一系列论文中展开。第三组与海马及其周围结构主要起着代表我们在太空中的位置(2014年诺贝尔生理学或医学奖授予三位研究者的位置)的观点相反,海马是通用的观点。声明性记忆的结构,空间的或非空间的。第一场和第三场争论的特征是发表了几乎完全相同的实验,这些实验显示出相反的结果。所有这三个争议均针对进行实验并直接进行辩论的单个科学家进行了讨论。第一个(beta / gamma亚基)强调科学研究中可再现性的价值,第二个(视觉皮层发育)强调新技术和更新科学模型的价值,第三个(海马体)使学生接触正在进行的,尽管正在讨论中, 辩论。

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