• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Clinical and Experimental Immunology >Autologous mixed lymphocyte reaction in man. XIV. Deficiency of the autologous mixed lymphocyte reaction in acquired immune deficiency syndrome (AIDS) and AIDS related complex (ARC). In vitro effect of purified interleukin-1 and interleukin-2.
【2h】

Autologous mixed lymphocyte reaction in man. XIV. Deficiency of the autologous mixed lymphocyte reaction in acquired immune deficiency syndrome (AIDS) and AIDS related complex (ARC). In vitro effect of purified interleukin-1 and interleukin-2.

机译：人的自体混合淋巴细胞反应。十四。获得性免疫缺陷综合症（AIDS）和AIDS相关复合物（ARC）的自体混合淋巴细胞反应不足。纯化的白介素-1和白介素-2的体外作用。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Peripheral blood mononuclear cells from male homosexuals with acquired immune deficiency syndrome (AIDS) and with AIDS related complex (ARC) were examined for the autologous mixed lymphocyte reaction (AMLR) between responder T and irradiated autologous non-T cells and in vitro influence of purified human interleukin-1 (IL-1) and -2 (IL-2) on the AMLR. The AMLR was significantly (P less than 0.001) deficient in both ARC and AIDS; the deficiency of the AMLR was of the similar magnitude in two groups when compared to asymptomatic homosexuals and healthy heterosexuals. In vitro addition of IL-2 enhanced the AMLR to the baseline levels of control subjects in most patients in ARC group (P less than 0.01) and in four of 15 patients in AIDS group (P less than 0.01). Addition of IL-1 to IL-2 containing cultures resulted in no further increase in the AMLR response over those with IL-2 alone. This study demonstrates deficiency of the AMLR in patients with ARC and AIDS that is corrected by purified IL-2 in the majority of cases with ARC but only a subset of patients with AIDS. The significance of these findings is discussed.
机译：检查来自获得性免疫缺陷综合症（AIDS）和AIDS相关复合物（ARC）的男性同性恋者的外周血单个核细胞在应答者T和辐射的自体非T细胞之间的自体混合淋巴细胞反应（AMLR）以及纯化后的体外影响AMLR上的人类白介素1（IL-1）和-2（IL-2）。 ARC和AIDS的AMLR明显不足（P小于0.001）;与无症状的同性恋者和健康的异性恋者相比，两组的AMLR缺乏程度相似。在ARC组的大多数患者中（P小于0.01），在AIDS组的15名患者中有四个（P小于0.01），在体外添加IL-2可将AMLR增强至对照组的基线水平。与单独使用IL-2的培养物相比，将IL-1添加到含IL-2的培养物中不会导致AMLR反应的进一步增加。这项研究表明，在大多数ARC病例中，ARC和AIDS患者的AMLR缺陷可通过纯化的IL-2纠正，但只有一部分AIDS患者。讨论了这些发现的意义。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号