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首页> 美国卫生研究院文献>Clinical and Experimental Immunology >Relationship of age and sex to autoantibody expression in MRL-+/+ and MRL-lpr/lpr mice: demonstration of an association between the expression of antibodies to histones denatured DNA and Sm in MRL-+/+ mice.
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Relationship of age and sex to autoantibody expression in MRL-+/+ and MRL-lpr/lpr mice: demonstration of an association between the expression of antibodies to histones denatured DNA and Sm in MRL-+/+ mice.

机译：年龄和性别与MRL-+ / +和MRL-lpr / lpr小鼠中自身抗体表达的关系：证明MRL-+ / +小鼠中针对组蛋白变性DNA和Sm的抗体表达之间的关联。

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Despite the protean nature of the clinical characteristics of systemic lupus erythematosus (SLE), autoantibodies represent an almost constant feature. Furthermore they are common to both human SLE and murine lupus. Nonetheless, the mechanism by which they arise has not been established. Amongst the several processes that have been proposed, evidence has emerged supporting specific antigen drive as a significant mechanism. We have documented the age- and sex-related differences in the prevalence of antibodies to both chromatin-related (histone and DNA) and non-chromatin-related (Sm) antigens in MRL mice. Our finding of an association between antihistone antibodies and anti-denatured DNA antibodies is consistent with chromatin being the putative antigen. Additionally, antibodies to the individual histones H1 and H2B, the most exposed histones in chromatin, were more prevalent than antibodies to the remaining histones (H2A, H3, H4). This, again, supports specific antigen drive as a mechanism for autoantibody production. However, associations were also found between antibodies to histone and DNA and antibodies to Sm. As Sm is a non-chromatin protein antigen, the associations between antibodies to Sm and those to histone and DNA suggest that mechanisms in addition to specific antigen drive are important in autoantibody production.
机译：尽管全身性红斑狼疮（SLE）的临床特征具有蛋白性质，但自身抗体几乎代表了恒定的特征。此外，它们对于人类SLE和鼠科狼疮都是共同的。但是，尚未建立产生它们的机制。在已经提出的几种方法中，已经出现了支持特异性抗原驱动作为重要机制的证据。我们已经在MRL小鼠中记录了与染色质相关（组蛋白和DNA）和非染色质相关（Sm）抗原的抗体的患病率的年龄和性别相关的差异。我们发现抗组蛋白抗体和抗变性DNA抗体之间存在关联，这与染色质是推定抗原是一致的。此外，针对单个组蛋白H1和H2B（染色质中最易暴露的组蛋白）的抗体比针对其余组蛋白（H2A，H3，H4）的抗体更为普遍。同样，这支持特异性抗原驱动作为自身抗体产生的机制。然而，在组蛋白和DNA的抗体与Sm的抗体之间也发现了关联。由于Sm是一种非染色质蛋白抗原，因此针对Sm的抗体与针对组蛋白和DNA的抗体之间的联系表明，除特异性抗原驱动外，其他机制在自身抗体生产中也很重要。

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