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首页> 美国卫生研究院文献>Clinical and Experimental Immunology >Measles virus inhibits lymphocyte proliferation in vitro by two different mechanisms.
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Measles virus inhibits lymphocyte proliferation in vitro by two different mechanisms.

机译：麻疹病毒通过两种不同的机制在体外抑制淋巴细胞增殖。

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We studied the effect of two different strains of measles virus (MV) on the lymphocyte blast transformation response. Infectious virus inhibited the proliferation response to PHA early during the culture when freshly isolated PBMC were stimulated. However, MV stimulated the proliferation of T cell lines early after infection and the inhibition was a late phenomenon associated with cell death. The early inhibition by the Edmonston strain of MV was shown to be monocyte-dependent by depletion studies with monoclonal antibodies. It could be partially explained by IFN-alpha production as the addition of anti-IFN-alpha antiserum to the cultures reversed the virus-induced inhibition and the addition of IFN reduced the response of uninfected PBMC. The late inhibition by the Edmonston strain was associated neither with monocytes nor with IFN-alpha but correlated with cell death in cultures. The inhibition by the Halle strain of MV was strong and associated with cell death already early after infection. The results demonstrate that MV inhibits lymphocyte proliferation by two different mechanisms and different virus strains vary both in the magnitude and mechanism of inhibition.
机译：我们研究了两种不同的麻疹病毒株（MV）对淋巴细胞转化反应的影响。当刺激新鲜分离的PBMC时，感染性病毒会在培养初期抑制对PHA的增殖反应。然而，MV在感染后早期刺激T细胞系的增殖，并且抑制是与细胞死亡相关的晚期现象。单克隆抗体的耗竭研究表明，埃德蒙斯顿菌株对MV的早期抑制作用是单核细胞依赖性的。可以用IFN-α产生来部分解释，因为在培养物中添加抗IFN-α抗血清可以逆转病毒诱导的抑制作用，而添加IFN可以降低未感染PBMC的反应。 Edmonston菌株的晚期抑制作用既不与单核细胞也不与IFN-α相关，而与培养物中的细胞死亡相关。 Halle菌株对MV的抑制作用很强，并且在感染后就已经与细胞死亡相关。结果表明，MV通过两种不同的机制抑制淋巴细胞的增殖，并且不同的病毒株在抑制的程度和机制上都不同。

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