• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Clinical and Experimental Immunology >Gender-related influences on the development of chronic graft-versus-host disease-induced experimental lupus nephritis.
【2h】

Gender-related influences on the development of chronic graft-versus-host disease-induced experimental lupus nephritis.

机译：慢性移植物抗宿主病诱发的实验性狼疮肾炎的发展与性别有关。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Autoimmune diseases are far more common in women than in men. In the incidence of systemic lupus erythematosus (SLE), the female-to-male ratio is as high as 10:1. This suggests that sex hormones may play a fundamental role in determining the susceptibility to these diseases. In order to investigate the sex-related differences in the inducibility of chronic graft-versus-host disease-related experimental lupus nephritis, lymphocytes from female DBA/2 donor mice were administered to either male or female (C57BL10 x DBA/2)F1 recipients. An additional group of male recipients received lymphocytes from male DBA/2 donors. After four cell transfers, female recipients developed a significantly higher albuminuria than both male groups. Serum concentrations of autoantibodies against glomerular basement membrane (GBM), collagen IV, and laminin were significantly higher in females 2-4 weeks after induction. Levels of circulating autoantibodies against renal tubular epithelial antigens (RTE) and nuclear antigens were not different between the sexes. In transfer studies, the necessity of the presence of anti-GBM and anti-RTE autoantibodies for the development of glomerulonephritis was confirmed. These findings indicate that: (i) in this model of lupus nephritis, susceptibility to glomerulonephritis is strongly influenced by sex-related genes; and (ii) among the variety of autoantibodies occurring in this model of SLE, both anti-GBM and anti-RTE autoantibodies play a key role in the pathogenesis of glomerulonephritis.
机译：女性自身免疫性疾病比男性普遍得多。在系统性红斑狼疮（SLE）的发病率中，男女之比高达10：1。这表明性激素可能在确定对这些疾病的易感性中起根本作用。为了研究与慢性移植物抗宿主病相关的实验性狼疮肾炎的可诱导性方面的性别相关差异，将雌性DBA / 2供体小鼠的淋巴细胞给予雄性或雌性（C57BL10 x DBA / 2）F1受体。另一组男性受体从男性DBA / 2供体接受淋巴细胞。经过四次细胞转移后，女性接受者的蛋白尿明显高于两组男性。诱导后2-4周的女性中，针对肾小球基底膜（GBM），胶原蛋白IV和层粘连蛋白的自身抗体的血清浓度明显更高。男女之间针对肾小管上皮抗原（RTE）和核抗原的循环自身抗体水平没有差异。在转移研究中，已证实存在抗GBM和抗RTE自身抗体用于肾小球肾炎的发展。这些发现表明：（i）在该狼疮性肾炎模型中，对肾小球性肾炎的易感性受到性相关基因的强烈影响； （ii）在这种SLE模型中出现的各种自身抗体中，抗GBM和抗RTE自身抗体在肾小球肾炎的发病机理中均起着关键作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号