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Pharmacokinetic-pharmacodynamic analysis of ciprofloxacin in elderly Chinese patients with lower respiratory tract infections caused by Gram-negative bacteria

机译：环丙沙星在中国老年人革兰氏阴性菌引起的下呼吸道感染中的药代动力学

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摘要

Background:Ciprofloxacin is usually used in the treatment of lower respiratory tract infections (LRTIs). Recent studies abroad have shown ciprofloxacin is inadequately dosed and might lead to worse outcomes. The aim of this study was to perform pharmacokinetic and pharmacodynamic analyses of ciprofloxacin in elderly Chinese patients with severe LRTIs caused by Gram-negative bacteria.

机译：背景：环丙沙星通常用于治疗下呼吸道感染（LRTI）。国外最近的研究表明环丙沙星剂量不足，可能导致更糟的结果。这项研究的目的是对由革兰氏阴性细菌引起的中国老年人患有严重LRTI的老年患者进行环丙沙星的药代动力学和药效学分析。

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期刊名称 Chinese Medical Journal
作者
Xiao-Yan Gai; Shi-Ning Bo; Ning Shen; Qing-Tao Zhou; An-Yue Yin; Wei Lu;
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作者单位

展开▼
年(卷),期 2019(132),6
年度 2019
页码 638–646
总页数 9
原文格式 PDF
正文语种
中图分类基础医学;
关键词
Ciprofloxacin Lower respiratory tract infection Pharmacokinetics;

机译：环丙沙星;下呼吸道感染;药代动力学;

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专利

1. Pharmacokinetic-pharmacodynamic analysis of ciprofloxacin in elderly Chinese patients with lower respiratory tract infections caused by Gram-negative bacteria [J] . Xiao-Yan Gai, Shi-Ning Bo, Ning Shen, 中华医学杂志（英文版） . 2019,第006期

机译：环丙沙星在中国老年人革兰氏阴性菌引起的下呼吸道感染中的药代动力学
2. Meropenem Dosing Based on a Population Pharmacokinetic-Pharmacodynamic Model in Elderly Patients with Infection of the Lower Respiratory Tract [J] . Zhou Qing-Tao, He Bei, Shen Ning, Drugs and aging . 2017,第2期

机译：基于人口药代动力学 - 药物动力学模型在患者患者患者患者下呼吸道感染的梅洛宁
3. Population pharmacokinetic analysis of ciprofloxacin in the elderly Paitients with lower respiratory tract infections [J] . Agnieszka Cios, Elzbieta Wyska, Joanna Szymura-Oleksiak, Experimental Gerontology . 2014,第Null期

机译：老年人下呼吸道感染患者环丙沙星的群体药代动力学分析
4. Comparision of Oral Levofloxacin and Ceftriaxone plus Clarithromycin in the Treatment of Hospitalized Patients with Lower Respiratory Tract Infections [C] . D.-W. Perng, H.-Y. Huang, Y.-C. Lee, Asian Pacific Society of Respirology . 2003

机译：口服左氧氟沙星和头孢曲松加上克拉霉素治疗住院治疗患者患者患者患者
5. Reovirus 1/L and influenza A infection of the upper and lower respiratory tracts: A paradigm for studies of the respiratory tract in the context of mucosal immunity. [D] . Thompson, Amy Hodson. 1998

机译：呼肠孤病毒1 / L和上下呼吸道的甲型流感感染：在粘膜免疫的背景下研究呼吸道的范例。
6. Distribution of pathogenic bacteria in lower respiratory tract infection in lung cancer patients after chemotherapy and analysis of integron resistance genes in respiratory tract isolates of uninfected patients [O] . Haiyan Liu, Bin Liu, Fade Zheng, 2020

机译：化疗后肺癌患者降低呼吸道感染的病原细菌分析及分析未感染患者呼吸道分离株的综合抗性基因
7. Cost-effectiveness analysis of oral versus intravenous drip infusion of levofloxacin in the treatment of acute lower respiratory tract infection in Chinese elderly patients [O] . Libin Zhang, Ping Hu 2017

机译：口腔抑制左氧氟沙星的口服与静脉滴注输注治疗中国老年患者急性下呼吸道感染的成本效益分析

Pharmacokinetic-pharmacodynamic analysis of ciprofloxacin in elderly Chinese patients with lower respiratory tract infections caused by Gram-negative bacteria

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