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首页> 美国卫生研究院文献>Cell Stress Chaperones >A pharmacological investigation of Hippophae salicifolia (HS) and Hippophae rhamnoides turkestanica (HRT) against multiple stress (C-H-R): an experimental study using rat model
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A pharmacological investigation of Hippophae salicifolia (HS) and Hippophae rhamnoides turkestanica (HRT) against multiple stress (C-H-R): an experimental study using rat model

机译：沙棘（HS）和沙棘沙棘（HRT）对多种应激（C-H-R）的药理研究：使用大鼠模型的实验研究

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Hippophae salicifolia (HS) and Hippophae rhamnoides turkestanica (HRT) are abundantly found species of Hippophae in Himalayan region of India. As these plants thrive under extreme climatic conditions, it is suspected that these plants must have a unique adaptogenic property against high-altitude stress. To keeping these views in our mind, the present study was planned to evaluate the mechanism of action of aqueous extract of HS and aqueous extract of HRT against multiple stress [cold-hypoxia-restraint (C-H-R)] for their adaptogenic activity. The present study reported the adaptogenic activity of HS in facilitating tolerance to multiple stress, CHR in rats. Pre-treatment with aqueous extract of HS significantly attenuated reactive oxygen species (ROS) production, protein oxidation, and lipid peroxidation and also showed role in maintaining antioxidant status as similar to control rats. Since protein oxidation was decreased by pre-treatment of HS, protein homeostasis was also sustained by regulation of heat shock proteins (HSP70 and HSP60). Interestingly, heme oxygenase-1 (HO-1), Vascular Endothelial Growth Factor (VEGF), and nitric oxide (NO) level was also increased in HS pre-treated rats depicted its adaptogenic activity against multiple stress, CHR. Conclusively, aqueous extract of HS could use an adaptogen for high altitude-associated multiple stress (CHR).
机译：沙棘（HS）和沙棘turkestanica（HRT）是印度喜马拉雅地区大量发现的沙棘物种。由于这些植物在极端气候条件下壮成长，因此怀疑这些植物必须具有针对高海拔胁迫的独特适应原性。为了记住这些观点，本研究计划评估HS的水提取物和HRT的水提取物针对其适应原性活性的多重应激作用（冷缺氧抑制（C-H-R））的作用机理。本研究报道了HS在促进大鼠对多种压力，CHR的耐受性中的适应性活性。用HS的水提取物进行预处理可显着减弱活性氧（ROS）的产生，蛋白质氧化和脂质过氧化作用，并且与对照组相比，在维持抗氧化剂状态方面也发挥了作用。由于通过HS预处理可以减少蛋白质氧化，因此还可以通过调节热激蛋白（HSP70和HSP60）来维持蛋白质稳态。有趣的是，在HS预处理的大鼠中，血红素加氧酶-1（HO-1），血管内皮生长因子（VEGF）和一氧化氮（NO）的水平也增加了，表明其对多种压力CHR的适应性活性。结论是，HS的水提取物可以使用适应原来应对高海拔相关的多重胁迫（CHR）。

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