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Recent Advances in Molecular Imaging of Premalignant Gastrointestinal Lesions and Future Application for Early Detection of Barrett Esophagus

机译:胃癌前病变的分子影像学研究进展及巴雷特食管早期检测的未来应用

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摘要

Recent advances in optical molecular imaging allow identification of morphologic and biochemical changes in tissues associated with gastrointestinal (GI) premalignant lesions earlier and in real-time. This focused review series introduces high-resolution imaging modalities that are being evaluated preclinically and clinically for the detection of early GI cancers, especially Barrett esophagus and esophageal adenocarcinoma. Although narrow band imaging, autofluorescence imaging, and chromoendoscopy are currently applied for this purpose in the clinic, further adoptions of probe-based confocal laser endomicroscopy, high-resolution microendoscopy, optical coherence tomography, and metabolomic imaging, as well as imaging mass spectrometry, will lead to detection at the earliest and will guide predictions of the clinical course in the near future in a manner that is beyond current advancements in optical imaging. In this review article, the readers will be introduced to sufficient information regarding this matter with which to enjoy this new era of high technology and to confront science in the field of molecular medical imaging.
机译:光学分子成像技术的最新进展可以更早,实时地识别与胃肠道(GI)恶变前病变相关的组织的形态和生化变化。该重点综述系列介绍了高分辨率成像模式,目前正在临床和临床上对其进行评估,以检测早期胃肠道癌症,尤其是巴雷特食管和食道腺癌。尽管目前在临床上为此目的应用了窄带成像,自发荧光成像和色谱内窥镜检查,但仍进一步采用基于探针的共聚焦激光内窥镜检查,高分辨率显微内窥镜检查,光学相干断层扫描和代谢组学成像以及成像质谱,最早将导致检测,并将以超出当前光学成像技术的方式指导临床病程的预测。在这篇评论文章中,将向读者介绍有关此问题的足够信息,以使他们享受高科技的新时代并与分子医学成像领域的科学相抗衡。

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