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首页> 美国卫生研究院文献>Clinical Cardiology >Quantitative evaluation of blood row distribution to exercising and resting skeletal muscles in patients with cardiac dysfunction using whole‐body thallium‐201 scintigraphy
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Quantitative evaluation of blood row distribution to exercising and resting skeletal muscles in patients with cardiac dysfunction using whole‐body thallium‐201 scintigraphy

机译：全身th 201闪烁显像技术定量评估心功能不全患者血液行分布对运动和休息骨骼肌的影响

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Background and hypothesis: Decreased blood flow to working muscles makes an important contribution to exercise intolerance in patients with chronic heart failure. This study was undertaken to examine whether maldistribution of skeletal muscle blood flow is closely related to exercise intolerance in patients with cardiac dysfunction. Methods: Whole‐body thallium scintigraphy was performed during one‐leg exercise in 11 patients with left ventricular (LV) dysfunction (LV ejection fraction <45%). Blood flow distribution to the exercising and resting legs was quantified by expressing regional thallium counts as a percentage of the whole‐body counts at rest, at the level of anaerobic threshold, and at peak exercise. Results: At anaerobic threshold, the thallium activity of exercising muscle increased from 4.2 ± 0.7 to 14.0 ± 2.5% (p< 0.05) in the thigh and from 1.7 ± 0.3 to 4.1 ± 0.9% (p<0.05) in the calf, compared with the resting value. Consequently, the ratio of thallium activity between exercising and resting legs increased to 2.7 ± 0.7 (p<0.05) in the thigh and to 2.3 ± 0.7 (p < 0.05) in the calf. When plotted as a function of anaerobic threshold, thallium activity of the exercising thigh (r = 0.78, p<0.05) and the thallium ratio between exercising and resting thigh (r = 0.69, p<0.05) declined with the reduction of exercise tolerance. These correlations were not observed in calves. Conclusion: Whole‐body thallium scintigraphy demonstrated a maldistribution of leg blood flow in patients with reduced aerobic exercise capacity, suggesting that this abnormality could play an important role in exercising intolerance in these patients.
机译：背景和假设：慢性心力衰竭患者活动肌肉的血流量减少是运动不耐的重要原因。这项研究的目的是检查心脏功能障碍患者骨骼肌血流的分布不均是否与运动耐量不足密切相关。方法：对11例左心室功能不全（LV射血分数<45％）的患者进行单腿运动时进行全身th闪烁显像。通过将区域resting计数表示为静止，无氧阈值水平和运动高峰时全身计数的百分比来量化运动和休息腿的血流量分布。结果：在无氧阈值下，小腿的运动肌肉and活动度从4.2±0.7增加到14.0±2.5％（p <0.05），小腿处从1.7±0.3增加到4.1±0.9％（p <0.05）具有静止值。因此，大腿和大腿之间exercising活动的比率增加到2.7±0.7（p <0.05），小腿则增加到2.3±0.7（p <0.05）。当绘制为无氧阈值的函数时，随着运动耐量的降低，运动大腿的th活性（r = 0.78，p <0.05）和运动与静止大腿之间的between比率（r = 0.69，p <0.05）下降。在牛犊中未观察到这些相关性。结论：全身th闪烁显像显示有氧运动能力下降的患者腿部血流分布不均，提示这种异常可能在这些患者的不耐受运动中起重要作用。

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