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A case of sudden hearing loss during treatment with decitabine for chronic myelomonocytic leukemia

机译:地西他滨治疗慢性粒细胞性白血病期间突然失聪的案例

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摘要

Chronic myelomonocytic leukemia (CMML) was initially classified in the category of myelodysplastic syndrome (MDS), but it is now categorized by the 2001 World Health Organization (WHO) classification in a separate nosological group of MDS. Unlike chronic myeloid leukemia (CML), the bone marrow morphology in CMML demonstrates prominent dysplastic changes in at least two of the three myeloid lineages. A 73-year-old male patient was brought to division of hematology for evaluation of leukocytosis. He was diagnosed with CMML and treated with decitabine. The hearing impairment had arisen during the third cycle of decitabine. To our knowledge, this is the first case that idiopathic sudden hearing loss (SHL) occured in CMML patients during treatment with decitabine.
机译:慢性粒细胞单核细胞白血病(CMML)最初被归类为骨髓增生异常综合症(MDS),但现在根据2001年世界卫生组织(WHO)归类为MDS的一个单独的疾病学类别。与慢性粒细胞白血病(CML)不同,CMML中的骨髓形态在三个髓样谱系中的至少两个中显示出显着的发育异常改变。一名73岁的男性患者被带到血液学部门评估白细胞增多症。他被诊断出患有CMML,并接受地西他滨治疗。在地西他滨的第三个周期中出现了听力障碍。据我们所知,这是第一个在地西他滨治疗期间CMML患者中发生特发性突然听力丧失(SHL)的情况。

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