Targeting PKCι-PAK1 signaling pathways in EGFR and KRAS mutant adenocarcinoma and lung squamous cell carcinoma

机译：在EGFR和KRAS突变型腺癌和肺鳞状细胞癌中靶向PKC1-PAK1信号通路

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Introductionp21-activated kinase 1 (PAK1) stimulates growth and metastasis in non-small cell lung cancer (NSCLC). Protein kinase C iota (PKCι) is an enzyme highly expressed in NSCLC, regulating PAK1 signaling. In the present study we explored whether the PKCι-PAK1 signaling pathway approach can be an efficient target in different types of NSCLC cell and mouse models.

机译：简介p21激活激酶1（PAK1）刺激非小细胞肺癌（NSCLC）的生长和转移。蛋白激酶C iota（PKC1）是在NSCLC中高度表达的调节PAK1信号转导的酶。在本研究中，我们探索了PKC1-PAK1信号通路途径是否可以成为不同类型的NSCLC细胞和小鼠模型中的有效靶标。

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期刊名称 Cell Communication and Signaling : CCS
作者
Masaoki Ito; Carles Codony-Servat; Jordi Codony-Servat; David Lligé; Imane Chaib; Xiaoyan Sun; Jing Miao; Rongwei Sun; Xueting Cai; Alberto Verlicchi; Morihito Okada; Miguel Angel Molina-Vila; Niki Karachaliou; Peng Cao; Rafael Rosell;
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年(卷),期 2019(17),-1
年度 2019
页码 137
总页数 11
原文格式 PDF
正文语种
中图分类细胞生物学;
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专利

1. Targeting PKCι-PAK1 signaling pathways in EGFR and KRAS mutant adenocarcinoma and lung squamous cell carcinoma [J] . Masaoki Ito, Carles Codony-Servat, Jordi Codony-Servat, Cell Communication and Signaling . 2019,第1期

机译：在EGFR和KRAS突变型腺癌和肺鳞癌中靶向PKC1-PAK1信号通路
2. P2.03-14 PKCi-PAK1 Pathway Modulates Sensitivity to Therapy in EGFR, KRAS Mutant and Squamous Cell Non-Small Cell Lung Cancer (NSCLC) [J] . M. Ito, C. Codony-Servat, J. Codony-Servat, Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer . 2018,第10期

机译：PKCI-PAK1 PKCI-PAK1途径调节EGFR，KRAS突变体和鳞状细胞非小细胞肺癌（NSCLC）的敏感性
3. Molecular Bases for Combinatorial Treatment Strategies in Patients with KRAS Mutant Lung Adenocarcinoma and Squamous Cell Lung Carcinoma [J] . Chiara Lazzari, Alberto Verlicchi, Anastasios Gkountakos, Pulmonary therapy. . 2016,第1期

机译：KRAS突变型肺腺癌和鳞状细胞肺癌患者联合治疗策略的分子基础
4. The effect of square wave stretching on proliferation of lung adenocarcinoma cells and Squamous Carcinoma of Tongue cells [C] . Qu Hua, Gao Peng 2010 3rd International Conference on Biomedical Engineering and Informatics . 2010

机译：方波拉伸对肺腺癌细胞和舌鳞状细胞癌增殖的影响
5. Gene expression analysis of human non -small cell lung cancer subtypes, adenocarcinoma and squamous cell carcinoma, and mouse lung epithelial cell lines: Implications in lung tumorigenesis [D] . Silvers, Amy Lynn. 2002

机译：人类非小细胞肺癌亚型，腺癌和鳞状细胞癌以及小鼠肺上皮细胞系的基因表达分析：在肺肿瘤发生中的意义
6. Functional signaling pathway analysis of lung adenocarcinomas identifies novel therapeutic targets for KRAS mutant tumors [O] . Elisa Baldelli, Guido Bellezza, Eric B. Haura, 2015

机译：肺腺癌的功能性信号通路分析确定了KRAS突变型肿瘤的新型治疗靶标
7. P2.03-45 PKCι-PAK1 Pathway Modulates Sensitivity to Therapy in EGFR, KRAS Mutant Adenocarcinoma and Squamous Cell Carcinoma [O] . M. Ito, C. Codony-Servat, J. Codony-Servat, 2019

机译：PKC1-PAK1途径调节EGFR，KRAS突变腺癌和鳞状细胞癌治疗的敏感性
8. Lung Squamous Cell Carcinoma Stem Cells as Immunotherapy Targets. [R] . Kim, C. 2017

机译：肺鳞状细胞癌干细胞作为免疫治疗靶点。

Targeting PKCι-PAK1 signaling pathways in EGFR and KRAS mutant adenocarcinoma and lung squamous cell carcinoma

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