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Mathematics Thermodynamics and Modeling to Address Ten Common Misconceptions about Protein Structure Folding and Stability

机译：数学热力学和建模解决关于蛋白质结构折叠和稳定性的十种常见误解

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摘要

To fully understand the roles proteins play in cellular processes, students need to grasp complex ideas about protein structure, folding, and stability. Our current understanding of these topics is based on mathematical models and experimental data. However, protein structure, folding, and stability are often introduced as descriptive, qualitative phenomena in undergraduate classes. In the process of learning about these topics, students often form incorrect ideas. For example, by learning about protein folding in the context of protein synthesis, students may come to an incorrect conclusion that once synthesized on the ribosome, a protein spends its entire cellular life time in its fully folded native confirmation. This is clearly not true; proteins are dynamic structures that undergo both local fluctuations and global unfolding events. To prevent and address such misconceptions, basic concepts of protein science can be introduced in the context of simple mathematical models and hands-on explorations of publicly available data sets. Ten common misconceptions about proteins are presented, along with suggestions for using equations, models, sequence, structure, and thermodynamic data to help students gain a deeper understanding of basic concepts relating to protein structure, folding, and stability.
机译：为了充分理解蛋白质在细胞过程中的作用，学生需要掌握有关蛋白质结构，折叠和稳定性的复杂思想。我们目前对这些主题的理解是基于数学模型和实验数据。但是，蛋白质结构，折叠和稳定性通常在本科班级中作为描述性，定性现象引入。在学习这些主题的过程中，学生经常形成错误的想法。例如，通过学习蛋白质合成过程中的蛋白质折叠，学生可能得出错误的结论，即一旦在核糖体上进行合成，蛋白质就将其整个细胞生命花费在其完全折叠的天然确认中。这显然是不正确的。蛋白质是同时经历局部波动和整体展开事件的动态结构。为了防止和解决这种误解，可以在简单的数学模型和对公开数据集的动手探索的背景下引入蛋白质科学的基本概念。提出了十种有关蛋白质的常见误解，并提出了使用方程式，模型，序列，结构和热力学数据的建议，以帮助学生更深入地了解与蛋白质结构，折叠和稳定性有关的基本概念。

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