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Novel adiponectin-resistin (AR) and insulin resistance (IRAR) indexes are useful integrated diagnostic biomarkers for insulin resistance type 2 diabetes and metabolic syndrome: a case control study

机译：新型脂联素抵抗素（AR）和胰岛素抵抗（IRAR）指数是用于胰岛素抵抗2型糖尿病和代谢综合征的有用的综合诊断生物标志物：一项病例对照研究

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BackgroundAdiponectin and resistin are adipokines which modulate insulin action, energy, glucose and lipid homeostasis. Meta-analyses showed that hypoadiponectinemia and hyperresistinemia are strongly associated with increased risk of insulin resistance, type 2 diabetes (T2DM), metabolic syndrome (MS) and cardiovascular disease. The aim of this study was to propose a novel adiponectin-resistin (AR) index by taking into account both adiponectin and resistin levels to povide a better indicator of the metabolic homeostasis and metabolic disorders. In addition, a novel insulin resistance (IRAR) index was proposed by integration of the AR index into an existing insulin resistance index to provide an improved diagnostic biomarker of insulin sensitivity.

机译：背景脂联素和抵抗素是调节胰岛素作用，能量，葡萄糖和脂质稳态的脂肪因子。荟萃分析显示，低脂联素血症和高抵抗素血症与胰岛素抵抗，2型糖尿病（T2DM），代谢综合征（MS）和心血管疾病的风险增加密切相关。这项研究的目的是通过考虑脂联素和抵抗素的水平提出一个新的脂联素-抵抗素（AR）指数，以提供更好的代谢稳态和代谢障碍指标。另外，通过将AR指数整合到现有的胰岛素抵抗指数中，提出了新的胰岛素抵抗（IRAR）指数，以提供改善的胰岛素敏感性诊断生物标志物。

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期刊名称 Cardiovascular Diabetology
作者
Cia-Hin Lau; Sekaran Muniandy;
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作者单位

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年(卷),期 2011(10),-1
年度 2011
页码 8
总页数 18
原文格式 PDF
正文语种
中图分类心血管疾病;
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专利

1. Novel adiponectin-resistin (AR) and insulin resistance (IRAR) indexes are useful integrated diagnostic biomarkers for insulin resistance, type 2 diabetes and metabolic syndrome: a case control study [J] . Cia-Hin Lau, Sekaran Muniandy Cardiovascular Diabetology . 2011,第1期

机译：新型脂联素-抵抗素（AR）和胰岛素抵抗（IRAR）指数是用于胰岛素抵抗，2型糖尿病和代谢综合征的有用的综合诊断生物标志物：一项病例对照研究
2. Circulating levels of insulin-like growth factor binding protein-1 in relation to insulin resistance, type 2 diabetes mellitus, and metabolic syndrome (Chennai Urban Rural Epidemiology Study 118) [J] . GokulakrishnanK., VelmuruganK., GanesanS., Metabolism: Clinical and Experimental . 2012,第1期

机译：与胰岛素抵抗，2型糖尿病和代谢综合征相关的类胰岛素生长因子结合蛋白-1的循环水平（Chennai城市农村流行病学研究118）
3. Deep analyses of the associations of a series of biomarkers with insulin resistance, metabolic syndrome, and diabetes risk in nondiabetic middle-aged and elderly individuals: results from a Chinese community-based study [J] . Shihui Fu, Ping Ping, Leiming Luo, Clinical Interventions in Aging . 2016,第3期

机译：对非糖尿病中老年人的一系列生物标志物与胰岛素抵抗，代谢综合征和糖尿病风险的关联的深入分析：一项基于中国社区的研究结果
4. Study of Reversibility of the Metabolic Syndrome and Insulin Resistance: The ANTIATERO-ALIM Study [C] . S. Dragan, C. Socaciu, I. Gergen, International Congress on Coronary Artery Disease . 2007

机译：代谢综合征和胰岛素抵抗的可逆性研究：抗肌醇 - ALIM研究
5. The relationship between insulin resistance syndrome, body fat distribution, dietary intake variables and subclinical atherosclerosis in obese type 2 diabetes. [D] . Hegazi, Refaat Mohamed. 2002

机译：肥胖2型糖尿病的胰岛素抵抗综合征，体脂分布，饮食摄入变量与亚临床动脉粥样硬化之间的关系。
6. Deep analyses of the associations of a series of biomarkers with insulin resistance metabolic syndrome and diabetes risk in nondiabetic middle-aged and elderly individuals: results from a Chinese community-based study [O] . Shihui Fu, Ping Ping, Leiming Luo, 2016

机译：对非糖尿病中老年人的一系列生物标志物与胰岛素抵抗代谢综合征和糖尿病风险之间关系的深入分析：一项基于中国社区的研究结果
7. Novel adiponectin-resistin (AR) and insulin resistance (IRAR) indexes are useful integrated diagnostic biomarkers for insulin resistance, type 2 diabetes and metabolic syndrome: a case control study [O] . Cia-Hin Lau, Sekaran Muniandy 2011

机译：新型脂联素抵抗素（AR）和胰岛素抵抗（IRAR）指数是用于胰岛素抵抗，2型糖尿病和代谢综合征的有用的综合诊断生物标志物：一项病例对照研究

Novel adiponectin-resistin (AR) and insulin resistance (IRAR) indexes are useful integrated diagnostic biomarkers for insulin resistance type 2 diabetes and metabolic syndrome: a case control study

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