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Antidiabetic treatment restores adiponectin serum levels and APPL1 expression but does not improve adiponectin-induced vasodilation and endothelial dysfunction in Zucker diabetic fatty rats

机译：抗糖尿病治疗可恢复脂联素的血清水平和APPL1表达但不能改善脂联素诱导的Zucker糖尿病脂肪大鼠的血管舒张和内皮功能障碍

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BackgroundAdiponectin is able to induce NO-dependent vasodilation in Zucker lean (ZL) rats, but this effect is clearly alleviated in their diabetic littermates, the Zucker diabetic fatty (ZDF) rats. ZDF rats also exhibit hypoadiponectinemia and a suppressed expression of APPL1, an adaptor protein of the adiponectin receptors, in mesenteric resistance arteries. Whether an antidiabetic treatment can restore the vasodilatory effect of adiponectin and improve endothelial function in diabetes mellitus type 2 is not known.

机译：背景脂联素能够在Zucker lean（ZL）大鼠中诱导NO依赖性血管舒张，但在其糖尿病同窝人Zucker糖尿病性脂肪（ZDF）大鼠中这种作用明显减轻。 ZDF大鼠在肠系膜阻力动脉中还表现出低脂联素血症和APPL1（脂联素受体的衔接蛋白）表达受到抑制。在2型糖尿病患者中，抗糖尿病药物能否恢复脂联素的血管舒张作用并改善其内皮功能尚不清楚。

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期刊名称 Cardiovascular Diabetology
作者
Peter M Schmid; Markus Resch; Christian Schach; Christoph Birner; Guenter A Riegger; Andreas Luchner; Dierk H Endemann;
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作者单位

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年(卷),期 2013(12),-1
年度 2013
页码 46
总页数 9
原文格式 PDF
正文语种
中图分类心血管疾病;
关键词
Adiponectin APPL1 AdipoR eNOS Insulin Metformin Diabetes mellitus type 2;

机译：脂联素;APPL1;AdipoR;eNOS;胰岛素;二甲双胍;2型糖尿病;

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专利

1. Antidiabetic treatment restores adiponectin serum levels and APPL1 expression, but does not improve adiponectin-induced vasodilation and endothelial dysfunction in Zucker diabetic fatty rats [J] . Peter M Schmid, Markus Resch, Christian Schach, Cardiovascular Diabetology . 2013,第1期

机译：抗糖尿病治疗可恢复脂联素的血清水平和APPL1表达，但不能改善脂联素诱导的Zucker糖尿病脂肪大鼠的血管舒张和内皮功能障碍
2. Effect of L-carnitine administration on serum insulin and adiponectin levels, and AMPK, APPL1 and PPARγ gene expression in STZ-induced diabetic rat liver [J] . B. Shahouzehi, K. Barkhordari, S. Aminizadeh, Ukrainian Biochemical Journal . 2017,第6期

机译：左旋肉碱对STZ诱导的糖尿病大鼠肝脏血清胰岛素和脂联素水平以及AMPK，APPL1和PPARγ基因表达的影响
3. Globular and full-length adiponectin induce NO-dependent vasodilation in resistance arteries of Zucker lean but not Zucker diabetic fatty rats. [J] . Schmid PM, Resch M, Steege A, American Journal of Hypertension . 2011,第3期

机译：球状和全长脂联素在祖克瘦人的抗性动脉中诱导NO依赖性血管舒张，但在祖克尔糖尿病性脂肪大鼠中不诱导。
4. Irbesartan improves endothelial dysfunction abnormal lipid profile proteinuria and liver dysfunction in Zucker diabetic fatty rats independent of glucose and insulin levels [O] . MUNEHISA SHIMAMURA, HIRONORI NAKAGAMI, TAKASHI SHIMOSATO, -1

机译：厄贝沙坦可改善Zucker糖尿病脂肪大鼠的内皮功能障碍异常脂质谱蛋白尿和肝功能障碍而与葡萄糖和胰岛素水平无关
5. Antidiabetic treatment restores adiponectin serum levels and APPL1 expression, but does not improve adiponectin-induced vasodilation and endothelial dysfunction in Zucker diabetic fatty rats [O] . Peter M Schmid, Markus Resch, Christian Schach, 2013

机译：抗糖尿病治疗可恢复脂联素的血清水平和APPL1表达，但不能改善脂联素诱导的Zucker糖尿病脂肪大鼠的血管舒张和内皮功能障碍

Antidiabetic treatment restores adiponectin serum levels and APPL1 expression but does not improve adiponectin-induced vasodilation and endothelial dysfunction in Zucker diabetic fatty rats

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