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首页> 美国卫生研究院文献>Cancers >Low Numbers of Vascular Vessels Correlate to Progression in Hormone-Naïve Prostate Carcinomas Undergoing Radical Prostatectomy
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Low Numbers of Vascular Vessels Correlate to Progression in Hormone-Naïve Prostate Carcinomas Undergoing Radical Prostatectomy

机译：激素少的前列腺癌行根治性前列腺切除术的血管数量少与进展相关

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Vascularization influences tumor development by supporting the nutrition and dissemination of tumor cells. On the other hand, a low number of vascular vessels (VVlow) may induce hypoxia, accounting for selection of resistant clone(s) of tumor cells. This study aimed to evaluate the prognostic significance of vascular (VV) and lymphatic vessels (LV) in prostate cancer (PCa). Tumor samples from 400 PCa patients undergoing radical prostatectomy (RP) were prepared in duplex as tissue microarrays. Numbers of VV and LV were evaluated using immunohistochemistry detecting CD34 and podoplanin, respectively, and correlated to clinical data, biochemical recurrence (BR), and proteins analyzed in tumor cells. VVlow and LV were found in 32% and 43% of patients with informative PCa samples, respectively. VVlow correlated with a shorter time to BR 3, 5, and 10 years after RP in hormone-naïve patients (p = 0.028, p = 0.027 and p = 0.056, respectively). It was also shown to be an independent prognostic factor 5 years after surgery (multivariate analysis, p = 0.046). Tumors characterized by VVlow expressed the epithelial cell adhesion molecule, EpCAM, less frequently (p = 0.016) and revealed a borderline correlation to increased levels of tumor cell invasion marker Loxl-2 (p = 0.059). No correlations were found for LV. In summary, VVlow in hormone-naïve patients undergoing RP has prognostic potential and seems to be related to an aggressive phenotype of tumor cells.
机译：血管化通过支持肿瘤细胞的营养和扩散影响肿瘤的发展。另一方面，少量血管（VV low ）可能会导致缺氧，这说明选择了肿瘤细胞的抗性克隆。本研究旨在评估血管（VV）和淋巴管（LV）在前列腺癌（PCa）中的预后意义。将来自400例接受根治性前列腺切除术（RP）的PCa患者的肿瘤样本作为组织微阵列进行双联制备。使用免疫组织化学检测CD34和Podoplanin分别评估VV和LV的数量，并将其与临床数据，生化复发（BR）和在肿瘤细胞中分析的蛋白质相关联。信息丰富的PCa样本的患者中分别发现VV low 和LV。在未接受激素的患者中，VV low 与RP发生BR后3、5和10年的时间较短有关（分别为p = 0.028，p = 0.027和p = 0.056）。它也被证明是术后5年的独立预后因素（多变量分析，p = 0.046）。以VV low 为特征的肿瘤表达上皮细胞粘附分子EpCAM的频率较低（p = 0.016），并且与肿瘤细胞浸润标志物Loxl-2的水平升高相关（p = 0.059）。 LV没有相关性。总而言之，未经激素治疗的RP患者中的VV low 具有预后潜力，似乎与肿瘤细胞的侵袭性表型有关。

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