This study was designed to compare the analgesic effects of butorphanol with those of meloxicam following ovariohysterectomy. Fifteen dogs were premedicated with 0.05 mg/kg body weight (BW) of acepromazine by intramuscular (IM) injection, plus 0.2 mg/kg BW of meloxicam by subcutaneous (SC) injection. Fifteen dogs were premedicated with 0.05 mg/kg BW of Acepromazine, IM, plus 0.2 mg/kg BW of butorphanol, IM. Anesthesia was induced with thiopental, and dogs were maintained on halothane. All pain measurements were performed by 1 experienced individual, blinded to treatment. Pain scores and visual analogue scales (VAS) were performed at 2, 3, 4, 6, 8, 12, and 24 hours postpremedication. An analgesiometer was used to determine the pressure required to produce an active avoidance response to pressure applied at the incision line. Pain scores, VAS, and analgesiometer scores were analyzed by using a generalized estimating equations method. A significance level of P < 0.05 was considered significant. Animals that received meloxicam demonstrated significantly lower pain scores and VAS than did animals that received butorphanol in the first 12 hours after surgery. Results of this study suggest that meloxicam will produce better postoperative analgesia than will butorphanol.Mucosal bleeding times were performed on cooperative animals in the study group (11 butorphanol, 13 meloxicam). Bleeding times were performed prior to premedication, 6 hours following premedication, and 24 hours after premedication. The 6- and 24-hour readings were compared with baseline bleeding times by using a paired t-test with a Bonferroni correction (a significance level of P < 0.025). Bleeding times did not change significantly over time.
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机译：这项研究旨在比较卵巢子宫切除术后丁苯啡诺和美洛昔康的镇痛作用。用肌肉注射（IM）注射15只狗以0.05 mg / kg体重（BW）的乙酰丙嗪和皮下注射（SC）注射0.2 mg / kg BW的美洛昔康。用0.05 mg / kg BW的乙丙嗪（IM）和0.2 mg / kg BW的异丙酚（IM）对15只狗进行药物治疗。用硫喷妥钠诱导麻醉，并用氟烷维持狗。所有疼痛测量均由1位对治疗无知的经验丰富的人员进行。在用药前2、3、4、6、8、12和24小时进行疼痛评分和视觉模拟量表（VAS）。使用止痛仪确定对切口线上施加的压力产生主动回避响应所需的压力。使用广义估计方程法分析疼痛评分，VAS和止痛计评分。 P <0.05的显着性水平被认为是显着的。接受美洛昔康的动物在手术后的前12小时内表现出的疼痛评分和VAS显着低于接受丁烷酚的动物。这项研究的结果表明美洛昔康比布托啡诺具有更好的术后镇痛作用。研究组在合作动物身上进行了粘膜出血时间（11个布托啡诺，13个美洛昔康）。出血时间在用药前，用药后6小时和用药后24小时进行。通过配对t检验和Bonferroni校正将6小时和24小时读数与基线出血时间进行比较（显着性水平P <0.025）。出血时间没有随时间明显变化。
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