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首页> 美国卫生研究院文献>Proceedings of the Royal Society B: Biological Sciences >Effects of Schistocephalus solidus infection on brain monoaminergic activity in female three-spined sticklebacks Gasterosteus aculeatus.
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Effects of Schistocephalus solidus infection on brain monoaminergic activity in female three-spined sticklebacks Gasterosteus aculeatus.

机译：固醇血吸虫感染对雌性三棘刺GGasterosteus aculeatus脑单胺能活动的影响。

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摘要

The three-spined stickleback Gasterosteus aculeatus is an intermediate host of the tapeworm Schistocephalus solidus. Changes in predator avoidance, foraging and shoaling behaviour have been reported in sticklebacks infested with S. solidus, but the mechanisms underlying parasite-induced behavioural changes are not understood. Monoamine neurotransmitters are involved in the control of behaviour and central monoaminergic systems are sensitive to various stressors. Thus, the behavioural effects of S. solidus infestation might be a reflection of changes in brain monoaminergic activity in the stickleback host. The concentrations of 5-hydroxytryptamine (5-HT), dopamine (DA), norepinephrine (NE) and their metabolites 5-hydroxy-indoleacetic acid (5-HIAA), homovanilic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG) were measured in the telencephalons, hypothalami and brainstems of parasitized and non-parasitized female sticklebacks held in the laboratory. The ratios of 5-HIAA:5-HT were significantly elevated in both the hypothalami and brainstems of infected sticklebacks. The concentrations of 5-HT and NE were significantly reduced in the telencephalons of infected fish as compared with controls, but there was no elevation of metabolite concentrations. The results are consistent with chronic stress in infected fish, but may also reflect other alterations of neuroendocrine status resulting from parasite infection.
机译：三棘刺背G Gasterosteus aculeatus是the虫Schistocephalus solidus的中间宿主。据报道，在固相链球菌感染的棘背类动物中，捕食者回避，觅食和浅滩行为的改变，但寄生虫引起的行为改变的机制尚不清楚。单胺神经递质参与行为的控制，中枢单胺能系统对各种应激源敏感。因此，固相链球菌侵染的行为效应可能反映了棘背宿主中脑单胺能活性的变化。 5-羟色胺（5-HT），多巴胺（DA），去甲肾上腺素（NE）及其代谢物的浓度5-羟吲哚乙酸（5-HIAA），高香草酸（HVA）和3-甲氧基-4-羟苯基乙二醇（ MHPG）在实验室中被寄生和未寄生雌性棘背动物的远脑，下丘脑和脑干中进行测量。 5-HIAA：5-HT的比率在被感染的back的下丘脑和脑干中均显着升高。与对照组相比，被感染鱼的末梢脑中5-HT和NE的浓度显着降低，但代谢物浓度没有升高。结果与受感染鱼的慢性压力一致，但也可能反映了寄生虫感染引起的神经内分泌状态的其他改变。

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