首页> 美国卫生研究院文献>Breast Cancer Research : BCR >Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer providing a potential target for therapy

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Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer providing a potential target for therapy

机译：表皮生长因子受体（EGFR）由Y-box结合蛋白1（YB-1）转录诱导在基底样乳腺癌中可以被易瑞沙抑制从而提供了潜在的治疗靶标

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IntroductionBasal-like breast cancers (BLBCs) are very aggressive, and present serious clinical challenges as there are currently no targeted therapies available. We determined the regulatory role of Y-box binding protein-1 (YB-1) on epidermal growth factor receptor (EGFR) overexpression in BLBC, and the therapeutic potential of inhibiting EGFR. We pursued this in light of our recent work showing that YB-1 induces the expression of EGFR, a new BLBC marker.

机译：简介基底样乳腺癌（BLBCs）具有非常强的侵袭性，并且由于目前没有针对性的治疗方法，因此也面临着严峻的临床挑战。我们确定了Y盒结合蛋白1（YB-1）对BLBC中表皮生长因子受体（EGFR）过表达的调节作用，以及抑制EGFR的治疗潜力。我们根据最近的工作进行了研究，结果表明YB-1诱导了一种新的BLBC标记EGFR的表达。

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期刊名称 Breast Cancer Research : BCR
作者
Anna L Stratford; Golareh Habibi; Arezoo Astanehe; Helen Jiang; Kaiji Hu; Eugene Park; Ashleen Shadeo; Timon PH Buys; Wan Lam; Trevor Pugh; Marco Marra; Torsten O Nielsen; Uwe Klinge; Peter R Mertens; Samuel Aparicio; Sandra E Dunn;
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年(卷),期 2007(9),5
年度 2007
页码 R61
总页数 14
原文格式 PDF
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中图分类肿瘤学;
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1. Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer, providing a potential target for therapy [J] . Anna L Stratford, Golareh Habibi, Arezoo Astanehe, Breast Cancer Research . 2007,第5期

机译：表皮生长因子受体（EGFR）由Y-box结合蛋白1（YB-1）转录诱导，在基底样乳腺癌中可以被易瑞沙抑制，为治疗提供了潜在靶点
2. Activating PIK3CA Mutations Induce an Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-regulated Kinase (ERK) Paracrine Signaling Axis in Basal-like Breast Cancer [J] . Young Christian D., Zimmerman Lisa J., Hoshino Daisuke, Molecular & cellular proteomics: MCP . 2015,第7期

机译：激活PIK3CA突变诱导基底样乳腺癌中的表皮生长因子受体（EGFR）/细胞外信号调节激酶（ERK）旁分泌信号轴。
3. Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells [J] . Anna L Stratford, Christopher J Fry, Curtis Desilets, Breast Cancer Research . 2008,第6期

机译：Y-box结合蛋白1丝氨酸102是基底样乳腺癌细胞中p90核糖体S6激酶的下游靶标
4. Targeting of Epidermal Growth Factor Receptor (EGFR)-positive pancreatic cancer cell lines with cetuximab-conjugated near-infrared silver sulphide quantum dots [C] . Peter L. Labib, Elnaz Yaghini, Mahshid Hashemkhani, International Photodynamic Association World Congress;Society of Photo-Optical Instrumentation Engineers;International Photodynamic Association . 2019

机译：西妥昔单抗缀合的近红外硫化银量子点靶向表皮生长因子受体（EGFR）阳性胰腺癌细胞系
5. Epidermal growth factor receptor overexpression as a target for imaging and radiotherapy of breast cancer. [D] . Reilly, Raymond Matthew. 1999

机译：表皮生长因子受体过表达作为乳腺癌成像和放射治疗的目标。
6. Activating PIK3CA Mutations Induce an Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-regulated Kinase (ERK) Paracrine Signaling Axis in Basal-like Breast Cancer [O] . Christian D. Young, Lisa J. Zimmerman, Daisuke Hoshino, 2015

机译：激活PIK3CA突变诱导基底样乳腺癌中的表皮生长因子受体（EGFR）/细胞外信号调节激酶（ERK）旁分泌信号轴。
7. Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer, providing a potential target for therapy [O] . Stratford, Anna L., Habibi, Golareh, Marra, Marco, 2007

机译：表皮生长因子受体（EGFR）由Y-box结合蛋白1（YB-1）转录诱导，在基底样乳腺癌中可以被易瑞沙抑制，从而提供了潜在的治疗靶标
8. Insulin-Like Growth Factor Binding Protein-1 Interacts with Integrins to Inhibit Insulin-Like Growth Factor-Induced Breast Cancer Growth and Migration [R] . Gross, J. M. 2003

机译：胰岛素样生长因子结合蛋白-1与整合素相互作用，抑制胰岛素样生长因子诱导的乳腺癌生长和迁移

Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer providing a potential target for therapy

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