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Insulin-Like Growth Factor Binding Protein-1 Interacts with Integrins to Inhibit Insulin-Like Growth Factor-Induced Breast Cancer Growth and Migration

机译：胰岛素样生长因子结合蛋白-1与整合素相互作用，抑制胰岛素样生长因子诱导的乳腺癌生长和迁移

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The insulin-like growth factor (IGF) system and extracellular matrix proteins are key regulators of the malignant breast cancer phenotype. Both IGFs and extracellular matrix proteins communicate wit epithelial cells by ligating cell surface receptors. Therefore, ligand-receptor interactions of the two systems are relevant treatment targets in breast cancer cell growth. Studies have shown that IGFBP-l can bind to IGF and prevent IGF from interacting with its receptor and inhibit breast cancer cell growth. IGFBP-1 has also been shown to interact with extracellular matrix protein receptors, integrins, on the cell surface through an Arg-Cly-Asp (RGD) integrin recognition sequence. This proposal will test the hypothesis that IGFBP-1 interrupts ligand-receptor interactions between extracellular matrix proteins and integrins. The key research accomplishment is the conclusion that expression of a mutant form of IGFBP-l that cannot bind integrins at reasonable levels is not technically achievable using the Pichia pastoris yeast expression system. An alternative approach will be used to express mutant IGFBP-1. The successful expression and purification of mutant IGFBP-1 protein is needed to test whether IGFBP-1 can be used as a strategy to neutralize integrin function in an RGD-dependent manner.

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作者
Gross, J. M.;
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年度 2003
页码 1-18
总页数 18
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Proteins; Breast cancer; Epithelium; Ligands; Yeasts; Cells(Biology); Receptor sites(Physiology); Insulin; Growth(Physiology); Integrins;

机译：蛋白质;乳腺癌;上皮;配体;酵母;细胞（生物学）;受体位点（生理学）;胰岛素;生长（生理学）;整合素;

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1. Serum insulin-like growth factor type 1, insulin-like growth factor-binding protein-1, and insulin-like growth factor-binding protein-3 concentrations in patients with thyroid dysfunction. [J] . Iglesias P, Bayon C, Mendez J, Thyroid: official journal of the American Thyroid Association . 2001,第11期

机译：甲状腺功能不全患者的血清胰岛素样生长因子1型，胰岛素样生长因子结合蛋白1和胰岛素样生长因子结合蛋白3浓度。
2. Serum free and total insulin-like growth factor-I, insulin-like growth factor binding protein-1 and insulin-like growth factor binding protein-3 Levels in healthy elderly individuals. Relation to self-reported quality of health and disability. [J] . Janssen JA, Stolk RP, Pols HA, Gerontology: International Journal of Experimental and Clinical Gerontology . 1998,第5期

机译：健康老年个体的无血清和总胰岛素样生长因子-1，胰岛素样生长因子结合蛋白-1和胰岛素样生长因子结合蛋白-3水平。与自我报告的健康和残疾质量有关。
3. Aerobic exercise training increases circulating insulin-like growth factor binding protein-1 concentration, but does not attenuate the reduction in circulating insulin-like growth factor binding protein-1 after a high-fat meal [J] . PriorS.J., JenkinsN.T., BrandauerJ., Metabolism: Clinical and Experimental . 2012,第3期

机译：有氧运动训练可增加高脂餐后循环胰岛素样生长因子结合蛋白-1的浓度，但不会减弱循环胰岛素样生长因子结合蛋白-1的减少。
4. EFFECT OF NUTRITIONAL STATUS ON PLASMA CONCENTRATIONS OF INSULINLIKE GROWTH FACTOR BINDING PROTEIN-3 AND INSULIN-LIKE GROWTH FACTOR-I IN PASTURE-FED HOLSTEIN-FRIESIAN COWS [C] . F.Y. OBESE, K.L. MACMILLAN, S. HUMPHRYS, Biennial Conference of the Australia Society of Animal Production . 2004

机译：营养状况对浆液蛋白3和胰岛素样生长因子-1在牧场喂养荷斯坦 - 弗里斯奶牛的血浆浓度对血浆浓度的影响
5. Evaluation of serum insulin-like growth factor binding proteins and the insulin-like growth factor binding protein-2 locus for potential associations with growth, carcass merit and meat quality in beef cattle. [D] . Pagan, Melvin. 2002

机译：评价血清胰岛素样生长因子结合蛋白和胰岛素样生长因子结合蛋白2位点与肉牛生长，屠体价值和肉质的潜在关联。
6. Correction: Insulin-like growth factor-independent insulin-like growth factor binding protein 3 promotes cell migration and lymph node metastasis of oral squamous cell carcinoma cells by requirement of integrin β1 [O] . Yi-Chen Yen, Jenn-Ren Hsiao, Shih Sheng Jiang, 2016

机译：校正：胰岛素样生长因子依赖性胰岛素样生长因子结合蛋白3通过整合素β1的需要促进口腔鳞状细胞癌细胞的迁移和淋巴结转移
7. Diurnal Variation of Serum Insulin-like Growth Factor Binding Protein-1 in Three Boys and Fasting Insulin-like Growth Factor Binding Protein-1 Levels in Normal Children [O] . Toru Yasunaga, Toshiaki Tanaka, Noriyuki Katsumata, 1996

机译：三个男孩中血清胰岛素样生长因子结合蛋白-1的昼夜变异，以及普通儿童中禁食胰岛素样生长因子结合蛋白-1水平

Insulin-Like Growth Factor Binding Protein-1 Interacts with Integrins to Inhibit Insulin-Like Growth Factor-Induced Breast Cancer Growth and Migration

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